Oral vaccine of Lactococcus lactis harbouring pandemic H1N1 2009 haemagglutinin1 and nisP anchor fusion protein elevates anti-HA1 sIgA levels in mice

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• 作者：Stella Siaw Xiu Joan ; Jee Pui-Fong ; Adelene Ai-Lian Song…
• 关键词：Influenza virus ; H1N1 ; Haemagglutinin ; Lactococcus lactis ; Oral vaccine ; Surface display ; Vaccine
• 刊名：Biotechnology Letters
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：38
• 期：5
• 页码：793-799
• 全文大小：500 KB
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• 作者单位：Stella Siaw Xiu Joan (1)
  Jee Pui-Fong (4) (5)
  Adelene Ai-Lian Song (1)
  Li-Yen Chang (4) (5)
  Khatijah Yusoff (2) (3)
  Sazaly AbuBakar (4) (5)
  Raha Abdul Rahim (1) (3)
  
  1. Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, University Putra Malaysia (UPM), 43400, Serdang, Selangor, Malaysia
  4. Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  5. Tropical Infectious Diseases Research and Education Centre (TIDREC), University of Malaya, Kuala Lumpur, Malaysia
  2. Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, University Putra Malaysia, Serdang, Selangor, Malaysia
  3. Institute of Bioscience, University Putra Malaysia, Serdang, Selangor, Malaysia
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Microbiology
  Biotechnology
  Applied Microbiology
  Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-6776

文摘

Objective An oral lactococcal-based vaccine which haboured the haemagglutinin1 (HA1) antigen fused to nisP anchor protein for the purpose of surface displaying the HA1 antigen was developed against H1N1 virus.