Towards the development of an oral vaccine against porcine cysticercosis: expression of the protective HP6/TSOL18 antigen in transgenic carrots cells

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• 作者：Elizabeth Monreal-Escalante ; Dania O. Govea-Alonso ; Marisela Hernández…
• 关键词：Cysticercosis ; Delivery system ; HP6/TSOL18 ; Oral vaccine ; Plant ; based vaccine ; Taenia ; Vaccination
• 刊名：Planta
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：243
• 期：3
• 页码：675-685
• 全文大小：960 KB
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• 作者单位：Elizabeth Monreal-Escalante (1)
  Dania O. Govea-Alonso (1)
  Marisela Hernández (2)
  Jacquelynne Cervantes (2)
  Jorge A. Salazar-González (1)
  Andrea Romero-Maldonado (1)
  Gabriela Rosas (3)
  Teresa Garate (4)
  Gladis Fragoso (2)
  Edda Sciutto (2)
  Sergio Rosales-Mendoza (1)
  
  1. Laboratorio de Biofarmacéuticos Recombinantes, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Dr. Manuel Nava 6, 78210, San Luis Potosí, Mexico
  2. Dpto. Inmunología. Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Circuito Escolar, Ciudad Universitaria, 04510, Mexico, D.F., Mexico
  3. Facultad de Medicina, Universidad Autónoma del Estado de Morelos, Cuernavaca, Mexico
  4. Dpto. de Parasitología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, 28220, Madrid, Spain
  
• 刊物主题：Plant Sciences; Agriculture; Ecology; Forestry;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-2048

文摘

Main conclusion The Taenia solium HP6/TSOL18 antigen was produced in carrot cells, yielding an immunogenic protein that induced significant protection in an experimental murine model against T. crassiceps cysticercosis when orally administered. This result supports the potential of HP6/TSOL18-carrot as a low-cost anti-cysticercosis vaccine candidate.