Lowest ever CD4 lymphocyte count (CD4 nadir) as a predictor of current cognitive and neurological status in human immunodeficiency virus type 1 infection—The Hawaii Aging with HIV Cohort
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- 作者：Victor Valcour (1) (2)
Priscilla Yee (3)
Andrew E. Williams (1)
Bruce Shiramizu (1)
Michael Watters (1)
Ola Selnes (4)
Robert Paul (5)
Cecilia Shikuma (1)
Ned Sacktor (4) - 关键词：AIDS dementia complex ; CD4 lymphocyte count ; polyneuropathies
- 刊名：Journal of NeuroVirology
- 出版年：2006
- 出版时间：September 2006
- 年：2006
- 卷：12
- 期：5
- 页码：387-391
- 全文大小：107KB
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Priscilla Yee (3)
Andrew E. Williams (1)
Bruce Shiramizu (1)
Michael Watters (1)
Ola Selnes (4)
Robert Paul (5)
Cecilia Shikuma (1)
Ned Sacktor (4)
1. Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, Hawaii, USA
2. Office of Neurology and Aging Research, Sinclair 202, Leahi Hospital, 3675 Kilauea Avenue, 96816, Honolulu, Hawaii, USA
3. John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
4. Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
5. Department of Psychology, Division of Behavioral Neuroscience, University of Missouri, St. Louis, Missouri, USA - ISSN：1538-2443
文摘
Low CD4 lymphocyte count was a marker for neurological disease in human immunodeficiency virus type 1 (HIV-1); but is now less common among patients with access to highly active antiretroviral therapy. In this study, the authors determine the reliability of self-reported CD4 nadir and its predictive value for neurological status. The authors identify a high degree of reliability (r = .90). After adjusting for age, current CD4 count, and duration of HIV-1, CD4 nadir relates to a current diagnosis of HIV-associated dimentia (HAD) (odds ratio [OR]: 1.395 (1.106-.761), P = .005) and distal symmetric polyneuropathy (DSPN) (OR: 1.479 (1.221-.769, P < .001).