参考文献:1. Kasiske BL, Vazquez MA, Harmon WE, Brown RS, Danovitch GM, Gaston RS, Roth D, Scandling JD, Singer GG, for the American Society of Transplantation: Recommendations for the outpatient surveillance of renal transplant recipients. / J Am Soc Nephrol 2000, 11:S1-S86. 2. Jeloka TK, Ross H, Smith R, Huang M, Fenton S, Cattran D, Schiff J, Cardella C, Cole E: Renal transplant outcome in high-cardiovascular risk recipients. / Clin Transplant 2007, 21:609鈥?14. CrossRef 3. Matignon M, Dahan K, Fruchaud G, Audard V, Grimbert P, Lang P: Kidney transplantation: indications, results, limitations, and perspectives. / Presse Med 2007, 36:1829鈥?834. CrossRef 4. Foster CE, Weng RR, Smith CV, Imagawa DK: The influence of organ acceptance criteria on long-term graft survival: outcomes of a kidney transplant program. / Am J Surg 2007, 195:149鈥?52. CrossRef 5. Johnston O, O'kelly P, Spencer S, John Donohoe, Walshe JJ, Little DM, Hickey D, Conlon PJ: Reduced graft function (with or without dialysis) vs immediate graft function鈥揳 comparison of long-term renal allograft survival. / Nephrol Dial Transplant 2006, 21:2270鈥?274. CrossRef 6. Sancho A, Gavela E, Avila A, Morales A, Fern谩ndez-N谩jera JE, Crespo JF, Pallardo LM: Risk factors and prognosis for proteinuria in renal transplant recipients. / Transplant Proc 2007, 39:2145鈥?147. CrossRef 7. Schaub S, Mayr M, H枚nger G, Bestland J, Steiger J, Regeniter A, Mihatsch MJ, Wilkins JA, Rush D, Nickerson P: Detection of subclinical tubular injury after renal transplantation: comparison of urine protein analysis with allograft histopathology. / Transplantation 2007, 84:104鈥?12. CrossRef 8. Braun WE: Renal transplantation: basic concepts and evolution of therapy. / J Clin Apher 2003, 18:141鈥?52. CrossRef 9. B枚hmig GA, Regele H, H枚rl WH: Protocol biopsies after kidney transplantation. / Transpl Int 2005, 18:131鈥?39. CrossRef 10. Goldsmith D, Al-Khoury S, Shah N, Covic A: Anaemia after renal transplantation鈥搑ole of immunosuppressive drugs and a pathophysiological appraisal. / Nephron Clin Pract 2006, 104:69鈥?4. CrossRef 11. Goldfarb S: Update in nephrology. / Ann Intern Med 2008, 148:49鈥?4. 12. Shipkova M, Armstrong VW, Oellerich M, Wieland E: Mycophenolate mofetil in organ transplantation: focus on metabolism, safety and tolerability. / Expert Opin Drug Metab Toxicol 2005, 1:505鈥?26. CrossRef 13. V铆tko S, Viklick媒 O: Cyclosporine renal dysfunction. / Transplant Proc 2004, 36:243S-247S. CrossRef 14. Scott LJ, McKeage K, Keam SJ, Plosker GL: Tacrolimus: a further update of its use in the management of organ transplantation. / Drugs 2003, 63:1247鈥?297. CrossRef 15. Drachenberg CB, Hirsch HH, Papadimitriou JC, Gosert R, Wali RK, Munivenkatappa R, Nogueira J, Cangro CB, Haririan A, Mendley S, Ramos E: Polyomavirus BK versus JC replication and nephropathy in renal transplant recipients: a prospective evaluation. / Transplantation 2007, 84:323鈥?30. CrossRef 16. Fishman JA, Emery V, Freeman R, Pascual M, Rostaing L, Schlitt HJ, Sgarabotto D, Torre-Cisneros J, Uknis ME: Cytomegalovirus in transplantation-challenging the status quo. / Clin Transplant 2007, 21:149鈥?58. CrossRef 17. Linares L, Cof谩n F, Cervera C, Ricart MJ, Oppenheimer F, Campistol JM, Moreno A: Infection-related mortality in a large cohort of renal transplant recipients. / Transplant Proc 2007, 39:2225鈥?227. CrossRef 18. Schweitzer EJ, Perencevich EN, Philosophe B, Bartlett ST: Estimated benefits of transplantation of kidneys from donors at increased risk for HIV or hepatitis C infection. / Am J Transplant 2007, 7:1515鈥?525. CrossRef 19. Randhawa P, Vats A, Shapiro R: The pathobiology of polyomavirus infection in man. / Adv Exp Med Biol 2006, 577:148鈥?59. CrossRef 20. Knowles WA: Discovery and epidemiology of the human polyomaviruses BK virus (BKV) and JC virus (JCV). / Adv Exp Med Biol 2006, 577:19鈥?5. CrossRef 21. Lundstig A, Dillner J: Serological diagnosis of human polyomavirus infection. / Adv Exp Med Biol 2006, 577:96鈥?01. CrossRef 22. Ashok A, Atwood WJ: Virus receptors and tropism. / Adv Exp Med Biol 2006, 577:60鈥?2. CrossRef 23. Doerries K: Human polyomavirus JC and BK persistent infection. / Adv Exp Med Biol 2006, 577:102鈥?16. CrossRef 24. Fioriti D, Videtta M, Mischitelli M, Degener AM, Russo G, Giordano A, Pietropaolo V: The human polyomavirus BK: Potential role in cancer. / J Cell Physiol 2005, 204:402鈥?06. CrossRef 25. Lee W, Langhoff E: Polyomavirus in human cancer development. / Adv Exp Med Biol 2006, 577:310鈥?18. CrossRef 26. Khalili K, White MK, Sawa H, Nagashima K, Safak M: The agnoprotein of polyomaviruses: a multifunctional auxiliary protein. / J Cell Physiol 2005, 204:1鈥?. CrossRef 27. Hirsch HH, Steiger J: Polyomavirus BK. / Lancet Infect Dis 2003, 3:611鈥?23. CrossRef 28. Kim HS, Henson JW, Frisque RJ: Transcription and replication in the human polyomaviruses. / Human Polyomaviruses / (Edited by: Wiley-Liss). INC. New York 2001, 73鈥?26. CrossRef 29. Agha I, Brennan DC: BK virus and immunosuppressive agents. / Adv Exp Med Biol 2006, 577:174鈥?84. CrossRef 30. Randhawa P, Zygmunt D, Shapiro R, Vats A, Weck K, Swalsky P, Finkelstein S: Viral regulatory region sequence variations in kidney tissue obtained from patients with BK virus nephropathy. / Kidney Int 2003, 64:743鈥?47. CrossRef 31. Hariharan S: BK virus nephritis after renal transplantation. / Kidney Int 2006, 69:655鈥?62. CrossRef 32. Hirsch HH: BK virus: opportunity makes a pathogen. / Clin Infect Dis 2005, 41:354鈥?60. CrossRef 33. Djamali A, Samaniego M, Muth B: Medical care of kidney transplant recipients after the first posttransplant year. / Clin J Am Soc Nephrol 2006, 1:623鈥?40. CrossRef 34. Pang XL, Doucette K, LeBlanc B, Cockfield SM, Preiksaitis JK: Monitoring of polyomavirus BK virus viruria and viremia in renal allograft recipients by use of a quantitative real-time PCR assay: one-year prospective study. / J Clin Microbiol 2007, 45:3568鈥?573. CrossRef 35. Drachenberg CB, Beskow CO, Cangro CB, Bourquin PM, Simsir A, Fink J, Weir MR, Klassen DK, Bartlett ST, Papadimitriou JC: Human polyomavirus in renal allograft biopsies: morphological findings and correlation with urine cytology. / Hum Pathol 1999, 30:970鈥?77. CrossRef 36. Hirsch HH, Knowles W, Dickenmann M, Passweg J, Klimkait T, Mihatsch MJ, Steiger J: Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients. / N Engl J Med 2002, 347:488鈥?96. CrossRef 37. Nickeleit V, Klimkait T, Binet IF, Dalquen P, Del Zenero V, Thiel G, Mihatsch MJ, Hirsch HH: Testing for polyomavirus type BK DNA in plasma to identify renal-allograft recipients with viral nephropathy. / N Engl J Med 2000, 342:1309鈥?315. CrossRef 38. Alangaden GJ, Thyagarajan R, Gruber SA, Morawski K, Garnick J, El-Amm JM, West MS, Sillix DH, Chandrasekar PH, Haririan A: Infectious complications after kidney transplantation: current epidemiology and associated risk factors. / Clin Transplant 2006, 20:401鈥?09. CrossRef 39. Beimler J, Sommerer C, Zeier M: The influence of immunosuppression on the development of BK virus nephropathy鈥揹oes it matter? / Nephrol Dial Transplant 2007, 22:66鈥?1. CrossRef 40. Giraldi C, Noto A, Tenuta R, Greco F, Perugini D, Dodaro S, Spadafora M, Lo Bianco AM, Savino O, Papalia T, Greco R, Bonofiglio R: Prospective study of BKV nephropathy in 117 renal transplant recipients. / New Microbiol 2007, 30:127鈥?30. 41. Latif S, Zaman F, Veeramachaneni R, Jones L, Uribe-Uribe N, Turbat-Herrera EA, Herrera GA: BK polyomavirus in renal transplants: role of electron microscopy and immunostaining in detecting early infection. / Ultrastruct Pathol 2007, 31:199鈥?07. CrossRef 42. Mannon RB, Hoffmann SC, Kampen RL, Cheng OC, Kleiner DE, Ryschkewitsch C, Curfman B, Major E, Hale DA, Kirk AD: Molecular evaluation of BK polyomavirus nephropathy. / Am J Transplant 2005, 5:2883鈥?3. CrossRef 43. Mischitelli M, Fioriti D, Anzivino E, Bellizzi A, Ferretti G, Gussman N, Mitterhofer AP, Tinti F, Barile M, Dal Maso M, Chiarini F, Pietropaolo V: BKV QPCR detection and infection monitoring in renal transplant recipients. / New Microbiol 2007, 30:271鈥?74. 44. Tong CY, Hilton R, MacMahon EM, Brown L, Pantelidis P, Chrystie IL, Kidd IM, Tungekar MF, Pattison JM: Monitoring the progress of BK virus associated nephropathy in renal transplant recipients. / Nephrol Dial Transplant 2004, 19:2598鈥?605. CrossRef 45. Vats A, Randhawa PS, Shapiro R: Diagnosis and treatment of BK virus-associated transplant nephropathy. / Adv Exp Med Biol 2006, 577:213鈥?27. CrossRef 46. Binet I, Nickeleit V, Hirsch HH, Prince O, Dalquen P, Gudat F, Mihatsch MJ, Thiel G: Polyomavirus disease under new immunosuppressive drugs: a cause of renal graft dysfunction and graft loss. / Transplantation 1999, 67:918鈥?22. CrossRef 47. Van Gorder MA, Della Pelle P, Henson JW, Sachs DH, Cosimi AB, Colvin RB: Cynomolgus polyoma virus infection: a new member of the polyoma virus family causes interstitial nephritis, ureteritis, and enteritis in immunosuppressed cynomolgus monkeys. / Am J Pathol 1999, 154:1273鈥?284. 48. Kapila K, Nampoory MR, Johny KV, Pacsa AS, Al-Ayadhy B, Mathew JR, Nair MP, Halim MA, George SS, Francis IM: Role of urinary cytology in detecting human polyoma bk virus in kidney transplant recipients. A preliminary report. / Med Princ Pract 2007, 16:237鈥?39. CrossRef 49. Kipp BR, Sebo TJ, Griffin MT, Ihrke JM, Halling KC: Analysis of Polyomavirus- Infected Renal Transplant Recipient's Urine Specimens. / Am J Clin Pathol 2005, 124:854鈥?61. CrossRef 50. Drachenberg CB, Papadimitriou JC: Polyomavirus-associated nephropathy: update in diagnosis. / Transpl Infect Dis 2006, 8:68鈥?5. CrossRef 51. Boldorini R, Veggiani C, Barco D, Monga G: Kidney and urinary tract polyomavirus infection and distribution: molecular biology investigation of 10 consecutive autopsies. / Arch Pathol Lab Med 2005, 129:69鈥?3. 52. Mannon RB: Polyomavirus nephropathy: what have we learned? / Transplantation 2004, 77:1313鈥?318. CrossRef 53. Drachenberg CB, Hirsch HH, Ramos E, Papadimitriou JC: Polyomavirus disease in renal transplantation: review of pathological findings and diagnostic methods. / Hum Pathol 2005, 36:1245鈥?255. CrossRef 54. Vera-Sempere FJ, Rubio L, Felipe-Ponce V, Garc铆a A, Mayordomo F, S谩nchez-Plumed J, Beneyto I, Ramos D, Zamora I, Sim贸n J: PCR assays for the early detection of BKV infection in 125 Spanish kidney transplant patients. / Clin Transplant 2006, 20:706鈥?11. CrossRef 55. Basse G, Mengelle C, Kamar N, Guitard J, Ribes D, Esposito L, Rostaing L: Prospective evaluation of BK virus DNAemia in renal transplant patients and their transplant outcome. / Transplant Proc 2007, 39:84鈥?7. CrossRef 56. Randhawa P, Ho A, Shapiro R, Vats A, Swalsky P, Finkelstein S, Uhrmacher J, Weck K: Correlates of quantitative measurement of BK polyomavirus (BKV) DNA with clinical course of BKV infection in renal transplant patients. / J Clin Microbiol 2004, 42:1176鈥?180. CrossRef 57. Leung AY, Chan M, Tang SC, Liang R, Kwong YL: Real-time quantitative analysis of polyoma BK viremia and viruria in renal allograft recipients. / J Virol Methods 2002, 103:51鈥?6. CrossRef 58. Limaye AP, Jerome KR, Kuhr CS, Ferrenberg J, Huang ML, Davis CL, Corey L, Marsh CL: Quantitation of BK virus load in serum for the diagnosis of BK virus-associated nephropathy in renal transplant recipients. / J Infect Dis 2001, 183:1669鈥?672. CrossRef 59. Hymes LC, Warshaw BL: Polyomavirus (BK) in pediatric renal transplants: evaluation of viremic patients with and without BK associated nephritis. / Pediatr Transplant 2006, 10:920鈥?22. CrossRef
作者单位:Monica Mischitelli (1) Anna Bellizzi (1) Elena Anzivino (1) Daniela Fioriti (1) Renzo Boldorini (2) Umberto Miglio (2) Fernanda Chiarini (1) Franco Di Monaco (3) Valeria Pietropaolo (1)
1. Department of Public Health Sciences, "La Sapienza" University, Rome, Italy 2. Department of Medical Sciences, Faculty of Medicine, University Amedeo Avogadro of East Piedmont, Novara, Italy 3. Department of Urology, "La Sapienza" University, Rome, Italy
ISSN:1743-422X
文摘
Clinical diagnosis of kidney transplants related illnesses is not a simple task. Several studies were conducted to define diseases and complications after renal transplantation, but there are no comprehensive guidelines about diagnostic tools for their prevention and detection. The Authors of this review looked for the medical literature and pertinent publications in particular to understand the role of Human Polyomavirus BK (BKV) in renal failure and to recognize analytical techniques for BK virus associated nephropathy (BKVAN) detection.