Wearable sensor-based objective assessment of motor symptoms in Parkinson's disease

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• 作者：Christiana Ossig ; Angelo Antonini ; Carsten Buhmann…
• 关键词：Parkinson’s disease (PD) ; Clinical scores ; Motor symptoms ; Objective measurement ; Accelerometer ; Gyroscope
• 刊名：Journal of Neural Transmission
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：123
• 期：1
• 页码：57-64
• 全文大小：423 KB
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• 作者单位：Christiana Ossig (1)
  Angelo Antonini (2)
  Carsten Buhmann (3)
  Joseph Classen (4)
  Ilona Csoti (5)
  Björn Falkenburger (6)
  Michael Schwarz (7)
  Jürgen Winkler (8)
  Alexander Storch (10) (11) (9)
  
  1. Department of Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité-Universitätsmedizin Berlin, 10117, Berlin, Germany
  2. Division of Parkinson Disease and Movement Disorders, Fondazione Ospedale, San Camillo, Venice, Italy
  3. Department of Neurology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany
  4. Department of Neurology, University of Leipzig, 04103, Leipzig, Germany
  5. Gertrudis-Kliniken im Parkinson Zentrum, Regionalzentrum Biskirchen, 35638, Leun-Biskirchen, Germany
  6. Department of Neurology, RWTH University Aachen, 52074, Aachen, Germany
  7. Neurologische Klinik, Klinikum Dortmund, 44137, Dortmund, Germany
  8. Division of Molecular Neurology, University Erlangen, 91054, Erlangen, Germany
  10. German Centre for Neurodegenerative Diseases (DZNE) Dresden, 01307, Dresden, Germany
  11. Department of Neurology, University of Rostock, 18147, Rostock, Germany
  9. Division of Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, 01307, Dresden, Germany
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Neurology
  Pharmacology and Toxicology
  Psychiatry
  
• 出版者：Springer Wien
• ISSN：1435-1463

文摘

Effective management and development of new treatment strategies of motor symptoms in Parkinson’s disease (PD) largely depend on clinical rating instruments like the Unified PD rating scale (UPDRS) and the modified abnormal involuntary movement scale (mAIMS). Regarding inter-rater variability and continuous monitoring, clinical rating scales have various limitations. Patient-administered questionnaires such as the PD home diary to assess motor stages and fluctuations in late-stage PD are frequently used in clinical routine and as clinical trial endpoints, but diary/questionnaire are tiring, and recall bias impacts on data quality, particularly in patients with cognitive dysfunction or depression. Consequently, there is a strong need for continuous and objective monitoring of motor symptoms in PD for improving therapeutic regimen and for usage in clinical trials. Recent advances in battery technology, movement sensors such as gyroscopes, accelerometers and information technology boosted the field of objective measurement of movement in everyday life and medicine using wearable sensors allowing continuous (long-term) monitoring. This systematic review summarizes the current wearable sensor-based devices to objectively assess the various motor symptoms of PD.