Genome-wide analysis of copy number variations identifies PARK2 as a candidate gene for autism spectrum disorder

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• 作者：Chia-Lin Yin ; Hsin-I Chen ; Ling-Hui Li ; Yi-Ling Chien ; Hsiao-Mei Liao…
• 关键词：PARK2 ; Autism spectrum disorder (ASD) ; Copy number variations (CNVs) ; Family study ; Gene expression
• 刊名：Molecular Autism
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：7
• 期：1
• 全文大小：1,360 KB
• 刊物主题：Neurology; Neurosciences; Neuropsychology; Molecular Medicine; Psychiatry; Pediatrics;
• 出版者：BioMed Central
• ISSN：2040-2392

文摘

Background Autism spectrum disorder (ASD) is an early-onset neurodevelopmental disorder with complex genetic underpinning in its etiology. Copy number variations (CNVs) as one of the genetic factors associated with ASD have been addressed in recent genome-wide association studies (GWAS). However, the significance of CNV has not been well investigated in non-Caucasian ASD population.