Mitochondria-targeted antioxidant SkQ1 accelerates maturation in Campbell dwarf hamsters (Phodopus campbelli)
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- 作者：K. A. Rogovin (1) (2)
A. M. Khrushcheva (1)
O. N. Shekarova (1)
M. V. Ushakova (1)
V. N. Manskikh (3)
N. Yu. Vasilieva (1) - 关键词：SkQ1 ; antioxidants ; mitochondria ; maturation ; lifespan ; Campbell dwarf hamsters
- 刊名：Biochemistry (Moscow)
- 出版年：2014
- 出版时间：October 2014
- 年：2014
- 卷：79
- 期：10
- 页码：1111-1116
- 全文大小：207 KB
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13. Rogovin, K. A., Khrushcheva, A. M., Shekarova, O. N., Ushakova, M. V., Manskikh, V. N., Sokolova, O. V., and Vasilieva, N. Yu. (2014) Effects of mitochondria-targeted plastoquinone derivative antioxidant (SkQ1) on demography of free breeding Campbell dwarf hamsters ( / Phodopus campbelli), kept in outdoor conditions. Reproduction, and life span: explanation in the framework of ultimate loads, / Biochemistry (Moscow), 79, 1117鈥?129. - 作者单位：K. A. Rogovin (1) (2)
A. M. Khrushcheva (1)
O. N. Shekarova (1)
M. V. Ushakova (1)
V. N. Manskikh (3)
N. Yu. Vasilieva (1)
1. Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Leninsky pr. 33, 119071, Moscow, Russia
2. Biological Faculty, Lomonosov Moscow State University, 119991, Moscow, Russia
3. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991, Moscow, Russia - ISSN：1608-3040
文摘
We tested two hypotheses. 1) SkQ1 positively affects postnatal development of hamsters in litters born to parents receiving long-term SkQ1 treatment. 2) SkQ1 accelerates maturation of juvenile females receiving the antioxidant treatment from 10 days of age. Parental pairs were kept in an outdoor vivarium under conditions close to natural. At the age of 25 days, juvenile males in litters born to parents treated daily with SkQ1 (50 nmol/kg per os) had higher epididymis mass. Both the size of a litter and SkQ1 affected epididymis mass in young males. Both the litter size and SkQ1 affected uterus mass in 25-day-old females. Juvenile females who received SkQ1 treatment from 10 days of age demonstrated earlier opening of the vagina. This experiment was replicated with the same result. At the age of 2.5 months, virgin females treated with SkQ1 from the early age demonstrated higher ovary mass.