Vascular endothelial growth factor and endoglin (CD-105) in gastric cancer
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- 作者：Nikolaos I. Nikiteas ; Nikolaos Tzanakis ; George Theodoropoulos ; Vassilios Atsaves ; Zoi Christoni ; Petros Karakitsos ; Andreas C. Lazaris ; Antonis Papachristodoulou ; Christos Klonaris and Maria Gazouli
- 关键词：VEGF ; CD ; 105 ; Gastric cancer ; Prognosis
- 刊名：Gastric Cancer
- 出版年：2007
- 出版时间：February, 2007
- 年：2007
- 卷：10
- 期：1
- 页码：12-17
- 全文大小：306 KB
- 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Oncology
Gastroenterology
Surgical Oncology
Pathology
Radiotherapy - 出版者：Springer Japan
- ISSN：1436-3305
文摘
Background Vascular endothelial growth factor (VEGF) overexpression has been associated with advanced stage and poor survival in several cancers. Additionally, CD-105 (endoglin) was proposed as a marker of neovascularization in solid malignancies. The aim of the present study was to (1) evaluate the VEGF and CD-105 expression in gastric carcinoma, (2) determine the role of VEGF gene sequence variations in VEGF expression in gastric carcinoma, and (3) correlate the results of VEGF and CD-105 expression with other standard prognostic parameters, such as size, grade, stage of the disease, metastases, and patient survival.