Prevalence of male accessory gland inflammations/infections in patients with Type 2 diabetes mellitus

详细信息    查看全文

• 作者：R. A. Condorelli ; A. E. Calogero ; E. Vicari…
• 关键词：Diabetes ; MAGI ; male infertility
• 刊名：Journal of Endocrinological Investigation
• 出版年：2013
• 出版时间：October 2013
• 年：2013
• 卷：36
• 期：9
• 页码：770-774
• 全文大小：
• 参考文献：1.Comhaire F, Verschraegen G, Vermeulen L. Diagnosis of accessory gland infection and its possible role in male infertility. Int J Androl 1980, 3: 32鈥?5.PubMed CrossRef
  2.Depuydt C, Zalata A, Christophe A, Mahmoud A, Comhaire F. Mechanisms of sperm deficiency in male accessory gland infection. Andrologia 1998, 30: 29鈥?3.PubMed CrossRef
  3.Krause W. Male accessory gland infection. Andrologia 2008, 40: 113鈥?.PubMed CrossRef
  4.La Vignera S, Vicari E, Condorelli RA, D鈥橝gata R, Calogero AE. Male accessory gland infection and sperm parameters (review). Int J Androl 2011, 34: e330鈥?7.PubMed CrossRef
  5.Keck C, Gerber-Sch盲fer C, Clad A, Wilhelm C, Breckwoldt M. Seminal tract infections: impact on male fertility and treatment options. Hum Reprod Update 1998, 4: 891鈥?03.PubMed CrossRef
  6.Askienazy-Elbhar M. Male genital tract infection: the point of view of the bacteriologist. Gynecol Obstet Fertil 2005, 33: 691鈥?.PubMed CrossRef
  7.Bezold G, Politch JA, Kiviat NB, Kuypers JM, Wolff H, Anderson DJ. Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia. Fertil Steril 2007, 87: 1087鈥?7.PubMed Central PubMed CrossRef
  8.Boitrelle F, Robin G, Lefebvre C, et al. Bacteriospermia in Assisted Reproductive Techniques: effects of bacteria on spermatozoa and seminal plasma, diagnosis and treatment. Gynecol Obstet Fertil 2012, 40: 226鈥?4.PubMed CrossRef
  9.Hedley AA, Ogden CL, Johnson CL, Carroll MD, Curtin LR, Flegal KM. Prevalence of overweight and obesity among US children, adolescents, and adults, 1999鈥?002. JAMA 2004, 291: 2847鈥?0.PubMed CrossRef
  10.Hannon TS, Rao G, Arslanian SA. Childhood obesity and type 2 diabetes mellitus. Pediatrics 2005, 116: 473鈥?0.PubMed CrossRef
  11.Liese AD, D鈥橝gostino RB, Hamman RF, et al. The burden of diabetes mellitus among US youth: prevalence estimates from the SEARCH for Diabetes in Youth Study. Pediatrics 2006, 118: 1510鈥?.PubMed CrossRef
  12.Dabelea D, Bell RA, D鈥橝gostino RB, et al. Incidence of diabetes in youth in the United States. JAMA 2007, 297: 2716鈥?4.PubMed CrossRef
  13.Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of obesity and trends in body mass index among US children and adolescents, 1999鈥?010. JAMA 2012, 307: 483鈥?0.PubMed CrossRef
  14.Comhaire FH, Mahmoud AM, Depuydt CE, Zalata AA, Christophe AB. Mechanisms and effects of male genital tract infection on sperm quality and fertilizing potential: the andrologist鈥檚 viewpoint. Hum Reprod Update 1999, 5: 393鈥?.PubMed CrossRef
  15.Marconi M, Pilatz A, Wagenlehner F, Diemer T, Weidner W. Impact of infection on the secretory capacity of the male accessory glands. Int Braz J Urol 2009, 35: 299鈥?08.PubMed CrossRef
  16.Kasturi SS, Tannir J, Brannigan RE. The metabolic syndrome and male infertility. J Androl 2008, 29: 251鈥?.PubMed CrossRef
  17.Bener A, Al-Ansari AA, Zirie M, Al-Hamaq AO. Is male fertility associated with type 2 diabetes mellitus? Int Urol Nephrol 2009, 41: 777鈥?4.PubMed CrossRef
  18.La Vignera S, Condorelli R, Vicari E, D鈥橝gata R, Calogero AE. Diabetes mellitus and sperm parameters. J Androl 2012, 33: 145鈥?3.PubMed CrossRef
  19.Rowe PJ, Comhaire FH, Hargreave TB, Mellows HJ. WHO Manual for the Standard Investigation and Diagnosis of the Infertile Couple. Cambridge: Cambridge University Press, 1993.
  20.WHO laboratory manual for the examination and processing of human semen. 5th edition, 2010.
  21.Rosen RC, Cappelleri JC, Smith MD, Lipsky J, Pena BM. Development and evaluation of an abridged, 5 item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res 1999, 11: 319鈥?6.PubMed CrossRef
  22.La Vignera S, Condorelli R, Vicari E, D鈥橝gata R, Calogero AE. High frequency of sexual dysfunction in patients with male accessory gland infections. Andrologia 2012, 44: 438鈥?6.PubMed CrossRef
  23.La Vignera S, Condorelli R, D鈥橝gata R, Vicari E, Calogero AE. Semen alterations and flow-citometry evaluation in patients with male accessory gland infections. J Endocrinol Invest 2012, 35: 219鈥?3.PubMed
  24.American Diabetes Association, Diagnosis and classification of Diabetes Mellitus. Diabetes Care 2010, 33: S62鈥?.PubMed Central CrossRef
  25.Associazione Medici Diabetologi (AMD) 鈥?Societ脿 Italiana di Diabetologia (SID). Standard italiani per la cura del diabete mellito 2009鈥?010. Torino: Infomedica 鈥?Formazione & informazione Medica, 2010.
  26.Renko M, Tapanainen P, Tossavainen P, Pokka T, Uhari M. Metaanalysis of the significance of asymptomatic bacteriuria in diabetes. Diabetes Care 2011, 34: 230鈥?.PubMed Central PubMed CrossRef
  27.Chen SL, Jackson SL, Boyko EJ. Diabetes mellitus and urinary tract infection: epidemiology, pathogenesis and proposed studies in animal models. J Urol 2009, 182: 51鈥?.CrossRef
  28.Balasubramanian K, Sivashanmugam P, Thameemdheen S, Govindarajulu P. Effect of diabetes mellitus on epididymal enzymes of adult rats. Indian J Exp Biol 1991, 29: 907鈥?.PubMed
  29.Ribeiro DL, Caldeira EJ, C芒ndido EM, Manzato AJ, Taboga SR, Cagnon VH. Prostatic stromal microenvironment and experimental diabetes. Eur J Histochem 2006, 50: 51鈥?0.PubMed
  30.Morrison JF, Dhanasekaran S, Howarth FC. Neuropeptides in the rat corpus cavernosum and seminal vesicle: effects of age and two types of diabetes. Auton Neurosci 2009, 146: 76鈥?0.PubMed CrossRef
  31.Morrison JF, Dhanasekaran S, Sheen R, Frampton CM, Mensah-Brown E. The effect of streptozotocin-induced diabetes on the rat seminal vesicle: A possible pathophysiological basis for disorders of ejaculation. Ann N Y Acad Sci 2006, 1084: 267鈥?9.PubMed CrossRef
  32.Rodriguez-Pena MS, Guijarro LG, Juarranz MG, et al. Analysis of vasoactive intestinal peptide receptors and the G protein regulation of adenylyl cyclase in seminal vesicle membranes from streptozotocin-diabetic rats. Cell Signal 1994, 6: 147鈥?6.PubMed CrossRef
  33.Chen HE, Xiao DZ. Changes of nerve growth factor and M3 subtype muscarinic receptor in the seminal vesicle of diabetic rats. Zhonghua Nan Ke Xue 2011, 17: 1002鈥?.PubMed
  34.Yonezawa A, Ebiko M, Yoshizumi M, et al. Effects of insulin replacement on ejaculatory dysfunction in streptozotocin-induced diabetic rats. Int J Urol 2009, 16: 208鈥?1.PubMed CrossRef
  35.La Vignera S, Vicari E, Condorelli R, D鈥橝gata R, Calogero AE. Ultrasound characterization of the seminal vesicles in infertile patients with type 2 diabetes mellitus. Eur J Radiol 2011, 80: e64鈥?.PubMed CrossRef
  36.La Vignera S, Condorelli RA, Di Mauro M, D鈥橝gata R, Vicari E, Calogero AE. Seminal vesicles and diabetic neuropathy: ultrasound evaluation. J Androl 2011, 32: 478鈥?3.PubMed CrossRef
  37.La Vignera S, Condorelli RA, Vicari E, D鈥橝gata R, Calogero AE. Seminal vesicles and diabetic neuropathy: ultrasound evaluation in patients with couple infertility and different levels of glycaemic control. Asian J Androl 2011, 13: 872鈥?.PubMed Central PubMed CrossRef
  38.La Vignera S, Calogero AE, Condorelli RA, et al. Ultrasonographic evaluation of patients with male accessory gland infection. Andrologia 2012, 44: 26鈥?1.PubMed CrossRef
  
• 作者单位：R. A. Condorelli (1)
  A. E. Calogero (1)
  E. Vicari (1)
  Y. Duca (1)
  V. Favilla (2)
  G. Morgia (2)
  S. Cimino (2)
  M. Di Mauro (1)
  S. La Vignera (1)
  
  1. Section of Endocrinology, Andrology and Internal Medicine, Department of Medical and Pediatric Sciences, University of Catania, Policlinico 鈥淕. Rodolico鈥? Via S. Sofia 78, Building 4, Room 2C18, 95123, Catania, Italy
  2. Department of Urology, University of Catania, Catania, Italy
  
• 刊物类别：Medicine/Public Health, general; Endocrinology; Metabolic Diseases;
• 刊物主题：Medicine/Public Health, general; Endocrinology; Metabolic Diseases;
• 出版者：Springer International Publishing
• ISSN：1720-8386

文摘

Background: MAGI is an acronym that identifies the 鈥渕ale accessory gland inflammations/infections鈥? a potential cause of male infertility. Type 2 diabetes mellitus (DM2) prevalence is going to increase among men of reproductive age. Due to the high prevalence of these two conditions, we could suppose that they might appear together in the same patient. Aim: To evaluate MAGI prevalence in patients with DM2 in fertile age. Subjects and methods: A cross-sectional study carried out on patients with DM2 of fertile age. All patients underwent andrological evaluation for the identification of conventional MAGI diagnostic criteria. Results: DM2 patients showed a frequency of MAGI about 43%, significantly lower (p<0.05) than in infertile patients of the same age without diabetes, which showed a MAGI overall frequency of 61%. Among examined diabetic patients the prevalence of MAGI did not significantly differ between patients attending for diabetes care problems (glycemic control) and patients with andrological disorders. Finally, no significant difference in seminal inflammatory signs frequency was detected between patients with DM2 and infertile patients without diabetes. Finally, the correlation analysis showed a significant direct correlation between duration of diabetes and glycemic control with the prevalence of MAGI. Conclusion: MAGI prevalence in DM2 is lower than the one detected in age-matched infertile non-diabetic patients, however, as in infertile patients, there is a high frequency of seminal inflammatory signs. Moreover, the observed prevalence among diabetic patients with diabetes care problems and diabetic patients with andrological problems is not statistically different. Key-words Diabetes MAGI male infertility