Maternal-fetal hepatic and placental metabolome profiles are associated with reduced fetal growth in a rat model of maternal obesity

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• 作者：Karen Mumme ; Clint Gray ; Clare M. Reynolds ; Mark H. Vickers…
• 关键词：Maternal obesity ; Fetal growth restriction ; Metabolomics ; Palmitoleic acid ; Fat
• 刊名：Metabolomics
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：12
• 期：5
• 全文大小：571 KB
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• 作者单位：Karen Mumme (1) (2)
  Clint Gray (1) (2)
  Clare M. Reynolds (1) (2)
  Mark H. Vickers (1) (2)
  Claudia J. Harrison (1) (2)
  Joanna L. Stanley (1) (2)
  Kathy Ruggiero (3)
  Silas G. Villas-Bôas (2) (4)
  Philip N. Baker (1) (2)
  Karolina Sulek (1) (2) (5)
  
  1. Liggins Institute, University of Auckland, Auckland, New Zealand
  2. Gravida: National Centre for Growth and Development, Auckland, New Zealand
  3. Department of Statistics, University of Auckland, Auckland, New Zealand
  4. School of Biological Sciences, University of Auckland, Auckland, New Zealand
  5. The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3b, 6.6.24, 2200 N, Copenhagen, Denmark
  
• 刊物主题：Biochemistry, general; Molecular Medicine; Cell Biology; Developmental Biology; Biomedicine general;
• 出版者：Springer US
• ISSN：1573-3890

文摘

Introduction Maternal obesity is associated with a range of pregnancy complications, including fetal growth restriction (FGR), whereby a fetus fails to reach its genetically determined growth. Placental insufficiency and reduced nutrient transport play a role in the onset of FGR.