Exploring the power of yeast to model aging and age-related neurodegenerative disorders
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- 作者：Ana V. Oliveira ; Rita Vilaça ; Cláudia N. Santos ; Vítor Costa…
- 关键词：Aging ; Neurodegenerative diseases ; Yeast models ; Parkinson’s disease ; Alzheimer’s disease ; Calorie restriction
- 刊名：Biogerontology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：18
- 期：1
- 页码：3-34
- 全文大小：
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Cell Biology; Geriatrics/Gerontology; Developmental Biology;
- 出版者：Springer Netherlands
- ISSN：1573-6768
- 卷排序：18
文摘
Aging is a multifactorial process determined by molecular, cellular and systemic factors and it is well established that advancing age is a leading risk factor for several neurodegenerative diseases. In fact, the close association of aging and neurodegenerative disorders has placed aging as the greatest social and economic challenge of the 21st century, and age-related diseases have also become a key priority for countries worldwide. The growing need to better understand both aging and neurodegenerative processes has led to the development of simple eukaryotic models amenable for mechanistic studies. Saccharomyces cerevisiae has proven to be an unprecedented experimental model to study the fundamental aspects of aging and to decipher the intricacies of neurodegenerative disorders greatly because the molecular mechanisms underlying these processes are evolutionarily conserved from yeast to human. Moreover, yeast offers several methodological advantages allowing a rapid and relatively easy way of establishing gene-protein-function associations. Here we review different aging theories, common cellular pathways driving aging and neurodegenerative diseases and discuss the major contributions of yeast to the state-of-art knowledge in both research fields.