Upper urinary tract urothelial cell carcinoma: location as a predictive factor for concomitant bladder carcinoma

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• 作者：Marco Cosentino (1)
  Joan Palou (1)
  Josep M. Gaya (1)
  Alberto Breda (1)
  Oscar Rodriguez-Faba (1)
  Humberto Villavicencio-Mavrich (1)
  
• 关键词：Upper tract urothelial carcinoma ; Bladder cancer ; Cancer recurrence ; Risk factors ; Concomitant
• 刊名：World Journal of Urology
• 出版年：2013
• 出版时间：February 2013
• 年：2013
• 卷：31
• 期：1
• 页码：141-145
• 全文大小：165KB
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• 作者单位：Marco Cosentino (1)
  Joan Palou (1)
  Josep M. Gaya (1)
  Alberto Breda (1)
  Oscar Rodriguez-Faba (1)
  Humberto Villavicencio-Mavrich (1)
  
  1. Urology Department, Fundació Puigvert, Universitat Autònoma de Barcelona, c/Cartagena 340, 08025, Barcelona, Spain
  
• ISSN：1433-8726

文摘

Objective To investigate the existence of predictive factors for concomitant, primary UUT-UCC and BC. Upper urinary tract urothelial cell carcinoma (UUT-UCC) is a pan-urothelial disease of the transitional epithelial cells. Although several studies have shown the association of bladder recurrence following UUT-UCC, little is known on the incidence of concomitant UUT-UCC and bladder cancer (BC) without previous BC. Materials and methods A retrospective review of 673 patients diagnosed and treated for UUT-UCC was performed. Patients with history of BC were excluded. We investigated age, sex, location of the upper tract tumor (calyx, renal pelvis, upper ureter, mid-ureter, lower ureter), multifocality, clinical symptoms, tumor grade and pathological stage. Contingency tables and chi-square test were used for categorical variables and analysis of variance (ANOVA) for quantitative variables. Results 450 patients eligible for inclusion were identified. Of these, 76 (17?%) presented concomitant primary UUT-UCC and BC. Location of primary UUT-UCC was in calyx and/or renal pelvis in 25 patients (34?%), upper ureter 8 (11?%) and lower ureter 37 (49?%). In 6 patients (8?%), data were missing. Concomitant BC was found in 10, 18, and 33?% of patients with primary caliceal/renal pelvis, upper ureter and lower ureter UUT-UCC, respectively. On multivariate analysis, location of UUT-UCC was the only predictive factor for concomitant bladder tumor (OR: 1.7; 95?% CI, 1.007-.906 p?=?0.047). Conclusions Our findings suggest that the possibility of concomitant BC in primary diagnosed patient with UUT-UCC is as high as 33?% and mainly depends on upper tract tumor location.