Phosphoinositide substrates of myotubularin affect voltage-activated Ca2+ release in skeletal muscle
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- 作者：Estela González Rodríguez (1)
Romain Lefebvre (2)
Dóra Bodnár (3)
Claude Legrand (2)
Peter Szentesi (3)
János Vincze (3)
Karine Poulard (4)
Justine Bertrand-Michel (5)
Laszlo Csernoch (3)
Anna Buj-Bello (4)
Vincent Jacquemond (2) - 关键词：Calcium homeostasis ; Excitation–contraction coupling ; Ryanodine receptor ; Sarcoplasmic reticulum Ca2+ release ; Phosphatidylinositol phosphate
- 刊名：Pfl篓鹿gers Archiv - European Journal of Physiology
- 出版年：2014
- 出版时间：May 2014
- 年：2014
- 卷：466
- 期：5
- 页码：973-985
- 全文大小：
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Romain Lefebvre (2)
Dóra Bodnár (3)
Claude Legrand (2)
Peter Szentesi (3)
János Vincze (3)
Karine Poulard (4)
Justine Bertrand-Michel (5)
Laszlo Csernoch (3)
Anna Buj-Bello (4)
Vincent Jacquemond (2)
1. Departamento de Fisiología, Genética y Microbiología, Universidad de Alicante, Alicante, Spain
2. Centre de Génétique et de Physiologie Moléculaire et Cellulaire, Université Lyon 1, UMR CNRS 5534, Bat. Rapha?l Dubois, 43 boulevard du 11 novembre 1918, F69622, Villeurbanne, France
3. Department of Physiology, University of Debrecen, Debrecen, Hungary
4. Department of Research and Development, Généthon, INSERM, Evry, France
5. Lipidomic Core Facility, Metatoul Platform, INSERM U1048, Université de Toulouse, Université Paul Sabatier, Toulouse, France - ISSN：1432-2013
文摘
Skeletal muscle excitation–contraction (E–C) coupling is altered in several models of phosphatidylinositol phosphate (PtdInsP) phosphatase deficiency and ryanodine receptor activity measured in vitro was reported to be affected by certain PtdInsPs, thus prompting investigation of the physiological role of PtdInsPs in E–C coupling. We measured intracellular Ca2+ transients in voltage-clamped mouse muscle fibres microinjected with a solution containing a PtdInsP substrate (PtdIns(3,5)P 2 or PtdIns(3)P) or product (PtdIns(5)P or PtdIns) of the myotubularin phosphatase MTM1. No significant change was observed in the presence of either PtdIns(5)P or PtdIns but peak SR Ca2+ release was depressed by ~30% and 50% in fibres injected with PtdIns(3,5)P 2 and PtdIns(3)P, respectively, with no concurrent alteration in the membrane current signals associated with the DHPR function as well as in the voltage dependence of Ca2+ release inactivation. In permeabilized muscle fibres, the frequency of spontaneous Ca2+ release events was depressed in the presence of the three tested phosphorylated forms of PtdInsP with PtdIns(3,5)P 2 being the most effective, leading to an almost complete disappearance of Ca2+ release events. Results support the possibility that pathological accumulation of MTM1 substrates may acutely depress ryanodine receptor-mediated Ca2+ release. Overexpression of a mCherry-tagged form of MTM1 in muscle fibres revealed a striated pattern consistent with the triadic area. Ca2+ release remained although unaffected by MTM1 overexpression and was also unaffected by the PtdIns-3-kinase inhibitor LY2940002, suggesting that the 3-phosphorylated PtdIns lipids active on voltage-activated Ca2+ release are inherently maintained at a low level, inefficient on Ca2+ release in normal conditions.