RP-HPLC Method for the Simultaneous Estimation of Eight Cardiovascular Drugs

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• 作者：Chiguru Vishnuvardhan (1)
  P. Radhakrishnanand (2)
  Sameer G. Navalgund (2)
  Krishnam Raju Atcha (3)
  N. Satheeshkumar (1)
  
• 关键词：Reversed ; phase liquid chromatography ; Cardiovascular drugs ; Pharmaceutical formulations ; JMP@ (SAS Institute) software
• 刊名：Chromatographia
• 出版年：2014
• 出版时间：February 2014
• 年：2014
• 卷：77
• 期：3-4
• 页码：265-275
• 全文大小：615 KB
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• 作者单位：Chiguru Vishnuvardhan (1)
  P. Radhakrishnanand (2)
  Sameer G. Navalgund (2)
  Krishnam Raju Atcha (3)
  N. Satheeshkumar (1)
  
  1. Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, 500037, India
  2. Research and Development Laboratory, United States Pharmacopeia-India Private Limited, ICICI Knowledge Park, Turkapally, Shameerpet, Hyderabad, India
  3. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, 500037, India
  
• ISSN：1612-1112

文摘

The present study describes a convenient method for the separation and simultaneous determination of eight drugs used in cardiovascular diseases, viz., atenolol (ATN), lisinopril (LISI), hydrochlorothiazide (HCTZ), enalapril maleate (ENA), amlodipine besylate (AMLO), losartan potassium (LOSA), valsartan (VAL) and atorvastatin calcium (ATOR) in pharmaceutical formulations. A ZORBAX Rx-C8 column (250?×?4.6?mm, 5?μm particle size) was used with mobile phase consisting of acetonitrile, 10?mM dipotassium hydrogen phosphate buffer (pH 2.2 adjusted with orthophosphoric acid) using a gradient program and quantitative evaluation was performed at 210?nm with a flow rate of 1.0?mL?min?. Suitability of this method for the quantitative determination of the drugs was proved by validation in accordance with International Conference on Harmonization guidelines. The method is selective, precise, robust, accurate and can be used for routine analysis of 15 combination pharmaceutical formulations in quality control.