Intravenous lidocaine 0.5 mg·kg-1 effectively suppresses fentanyl-induced cough

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• 作者：Chandra Kant Pandey (1)
  Mehdi Raza (1)
  Rajeev Ranjan (1)
  Vinay Singhal (1)
  Mukesh Kumar (1)
  Archana Lakra (1)
  Deepa Vishwas Navkar (1)
  Anil Agarwal (1)
  Ram Badan Singh (1)
  Uttam Singh (1)
  Prabhat Kumar Singh (1)
  
• 刊名：Canadian Journal of Anesthesia/Journal canadien d'anesth篓娄sie
• 出版年：2005
• 出版时间：February 2005
• 年：2005
• 卷：52
• 期：2
• 页码：172-175
• 全文大小：64KB
• 参考文献：1. / Agarwal A, Azim A, Ambesh S, et al. Salbutamol, beclomethasone or sodium chromoglycate suppress coughing induced by iv fentanyl. Can J Anesth 2003; 50: 297-00.
  2. / Tweed WA, Dakin D. Explosive coughing after bolus fentanyl injection. Anesth Analg 2001; 92: 1442-. CrossRef
  3. / Bohrer H, Fleischer F, Werning P. Tussive effect of a fentanyl bolus administered through a central venous catheter. Anaesthesia 1990; 45: 18-1. CrossRef
  4. / Phua WT, Teh BT, Jong W, Lee TL, Tweed WA. Tussive effect of a fentanyl bolus. Can J Anaesth 1991; 38: 330-.
  5. / Yukioka H, Yoshimoto N, Nishimura K, Fujimori M. Intravenous lidocaine as a suppressant of coughing during tracheal intubation. Anesth Analg 1985; 64: 1189-2. CrossRef
  6. / Smith FR, Kundahl PC. Intravenously administered lidocaine as cough depressant during general anesthesia for bronchography. Chest 1973, 63: 427-. CrossRef
  7. / Baraka A. Intravenous lidocaine controls extubation laryngospasm in children. Anesth Analg 1978; 57: 506-. CrossRef
  8. / Poulton TJ, James FM III. Cough suppression by lidocaine. Anesthesiology 1979; 50: 470-. CrossRef
  9. / Nishino T, Hiraga K, Sugimori K. Effects of i.v. lignocaine on airway reflexes elicited by irritation of the tracheal mucosa in humans anaesthetized with enflurane. Br J Anaesth 1990; 64: 682-. CrossRef
  10. / Yukioka H, Hayashi M, Terai T, Fujimori M. Intravenous lidocaine as a suppressant of coughing during tracheal intubation in elderly patients. Anesth Analg 1993; 77: 309-2. CrossRef
  11. / Pandey CK, Raza M, Ranjan R, et al. Intravenous lidocaine suppresses fentanyl-induced coughing: a double-blind, prospective, randomized placebo-controlled study. Anesth Analg 2004; 99: 1696-. CrossRef
  12. / Lui PW, Hsing CH, Chu YC. Terbutaline inhalation suppresses fentanyl-induced coughing. Can J Anaesth 1996; 43: 1216-. CrossRef
  13. / Yasuda I, Hirano T, Yusa T, Satoh M. Tracheal constriction by morphine and by fentanyl in man. Anesthesiology 1978: 49: 117-. CrossRef
  14. / Stellato C, Cirillo R, de Paulis A, et al. Human basophil/mast cell releasability. IX. Heterogeneity of the effects of opioids on mediator release. Anesthesiology 1992; 77: 932-0. CrossRef
  15. / Ricciardolo FL. Mechanisms of citric acid-induced bronchoconstriction. Am J Med 2001; 111: 18S-24S. CrossRef
  
• 作者单位：Chandra Kant Pandey (1)
  Mehdi Raza (1)
  Rajeev Ranjan (1)
  Vinay Singhal (1)
  Mukesh Kumar (1)
  Archana Lakra (1)
  Deepa Vishwas Navkar (1)
  Anil Agarwal (1)
  Ram Badan Singh (1)
  Uttam Singh (1)
  Prabhat Kumar Singh (1)
  
  1. From the Departments of Anaesthesiology and Biostatistics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, 226014, Lucknow, India
  

文摘

Purpose To evaluate the minimal dose of lidocaine required for suppression of fentanyl-induced cough. Methods 320 ASA I and II patients, non-smokers of both sexes scheduled for elective surgery between the ages of 18 to 60 yr were randomly allocated into four equal groups. The patients were assigned to receive lidocaine 0.5 mg·kg-1 (Group I), 1.0 mg·kg-1(Group II), 1.5 mg·kg-1 (Group III) or placebo (Group IV) over five seconds, one minute prior to the administration of fentanyl 3 μg·kg-1 in a randomized and double-blind fashion. Any episode of cough was classified as coughing and graded as mild (1-) moderate (3-) or severe (5 or more). The data were analyzed by test of proportion. Results Eleven, 12, 1 1 and 28 patients (13.75%, 15%, 13.75% and 35%) had cough in Groups I, II, III and IV respectively (P < 0.05 Groups I, II, III vs IV). There was no significant difference in the incidence and severity of cough among the lidocaine pretreated groups (P > 0.05). Conclusion The results of our study suggest that iv lidocaine 0.5 mg·kg-1 is the minimal dose required to suppress fentanyl-induced cough when administered one minute prior to fentanyl. Any further increase in the lidocaine dose does not reduce the incidence or severity of fentanyl-induced cough.