World Workshop on Oral Medicine VI: a systematic review of medication-induced salivary gland dysfunction: prevalence, diagnosis, and treatment
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- 作者：Alessandro Villa ; Andy Wolff ; Doron Aframian ; Arjan Vissink…
- 关键词：Xerostomia ; Saliva ; Medications ; Salivary gland dysfunction
- 刊名：Clinical Oral Investigations
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：19
- 期：7
- 页码：1563-1580
- 全文大小：732 KB
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Andy Wolff (2)
Doron Aframian (3)
Arjan Vissink (4)
J枚rgen Ekstr枚m (5)
Gordon Proctor (6)
Richard McGowan (7)
Nagamani Narayana (8)
Ardita Aliko (10) (9)
Ying Wai Sia (11)
Revan Kumar Joshi (12)
Siri Beier Jensen (13)
Alexander Ross Kerr (7)
Colin Dawes (14)
Anne Marie Lynge Pedersen (13)
1. Division of Oral Medicine and Dentistry, Brigham and Women鈥檚 Hospital, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, USA
2. Tel-Aviv Sourasky Medical Center and Saliwell Ltd, 65 Hatamar St., 60917, Harutzim, Israel
3. The Hebrew University, Jerusalem, Israel
4. Department of Oral and Maxillofacial Surgery, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands
5. Department of Pharmacology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
6. Dental Institute, King鈥檚 College London, London, UK
7. College of Dentistry, New York University, New York, NY, USA
8. Department of Oral Biology, College of Dentistry, UNMC, Lincoln, NE, USA
10. Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway
9. Faculty of Dental Medicine, University of Medicine, Tirana, Albania
11. McGill University, Quebec, QC, Canada
12. DAPMRV Dental College,, Bangalore, India
13. Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
14. Department of Oral Biology, University of Manitoba, Winnipeg, MB, Canada - 刊物类别：Medicine
- 刊物主题：Dentistry
- 出版者：Springer Berlin / Heidelberg
- ISSN：1436-3771
文摘
Objectives Medication-induced salivary gland dysfunction (MISGD) causes significant morbidity resulting in decreased quality of life. This systematic review assessed the literature on the prevalence, diagnosis, treatment, and prevention of MISGD. Materials and methods Electronic databases were searched for articles related to MISGD through June 2013. Four independent reviewers extracted information regarding study design, study population, interventions, outcomes, and conclusions for each article. Only papers with acceptable degree of relevance, quality of methodology, and strength of evidence were retained for further analysis. Results There were limited data on the epidemiology of MISGD. Furthermore, various methods were used to assess salivary flow rate or xerostomia. Preventive and therapeutic strategies included substitution of medications, oral, or systemic therapy with sialogogues, use of saliva substitutes or of electro-stimulating devices. Although there are promising approaches to improve salivary gland function, most studies are characterized by small numbers and heterogeneous methods. Conclusions Physicians and dentists should identify the medications associated with xerostomia and salivary gland dysfunction through a thorough medical history. Preferably, health care providers should measure the unstimulated and stimulated whole salivary flow rates of all their patients so that these values can be used as a baseline to rate the complaints of patients who subsequently claim to experience xerostomia or salivary gland dysfunction as well as the possibilities of effectively treating this condition. Clinical relevance MISGD remains a major burden for the population. This systematic review provides a contemporary in-depth description of the diagnosis and treatment of MISGD.