HbA1c, fasting and 2h plasma glucose in current, ex- and never-smokers: a meta-analysis
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- 作者：Soraya Soulimane (1) (2)
Dominique Simon (1) (3) (4)
William H. Herman (5)
Celine Lange (1) (2)
Crystal M. Y. Lee (6)
Stephen Colagiuri (6)
Jonathan E. Shaw (7)
Paul Z. Zimmet (7)
Dianna Magliano (7)
Sandra R. G. Ferreira (8)
Yanghu Dong (10) (9)
Lei Zhang (10) (9)
Torben Jorgensen (11)
Jaakko Tuomilehto (12) (13) (14)
Viswanathan Mohan (15)
Dirk L. Christensen (16)
Lydia Kaduka (17)
Jacqueline M. Dekker (18)
Giel Nijpels (19)
Coen D. A. Stehouwer (20)
Olivier Lantieri (21)
Wilfred Y. Fujimoto (22)
Donna L. Leonetti (23)
Marguerite J. McNeely (22)
Knut Borch-Johnsen (24)
Edward J. Boyko (22) (25)
Dorte Vistisen (26)
Beverley Balkau (1) (2) - 关键词：FPG ; HbA1c ; 2H ; PG ; Meta ; analysis ; Smoking
- 刊名：Diabetologia
- 出版年：2014
- 出版时间：January 2014
- 年：2014
- 卷：57
- 期：1
- 页码：30-39
- 全文大小：
- 作者单位：Soraya Soulimane (1) (2)
Dominique Simon (1) (3) (4)
William H. Herman (5)
Celine Lange (1) (2)
Crystal M. Y. Lee (6)
Stephen Colagiuri (6)
Jonathan E. Shaw (7)
Paul Z. Zimmet (7)
Dianna Magliano (7)
Sandra R. G. Ferreira (8)
Yanghu Dong (10) (9)
Lei Zhang (10) (9)
Torben Jorgensen (11)
Jaakko Tuomilehto (12) (13) (14)
Viswanathan Mohan (15)
Dirk L. Christensen (16)
Lydia Kaduka (17)
Jacqueline M. Dekker (18)
Giel Nijpels (19)
Coen D. A. Stehouwer (20)
Olivier Lantieri (21)
Wilfred Y. Fujimoto (22)
Donna L. Leonetti (23)
Marguerite J. McNeely (22)
Knut Borch-Johnsen (24)
Edward J. Boyko (22) (25)
Dorte Vistisen (26)
Beverley Balkau (1) (2)
1. CESP U1018, Inserm, 16 Avenue Paul Vaillant Couturier, 94807, Villejuif cedex, France
2. UMRS 1018, UniversitParis Sud 11, Villejuif, France
3. Diabetes Department, Groupe Hospitalier PitiSalpetrie, Paris, France
4. UniversitPierre et Marie Curie, Paris, France
5. University of Michigan, Ann Arbor, MI, USA
6. The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, University of Sydney, Sydney, NSW, Australia
7. Baker IDI Heart and Diabetes Institute, Melbourne, VIC, Australia
8. Department of Nutrition, School of Public Health, University of So Paulo, So Paulo, Brazil
10. Weifang Medical University, Weifang, People Republic of China
9. Department of Endocrinology and Metabolism, Qingdao Endocrine and Diabetes Hospital, Qingdao, People Republic of China
11. Research Centre for Prevention and Health, The Capital Region of Denmark, Glostrup, Denmark
12. Danube University Krems, Krems, Austria
13. Center for Vascular Prevention Red RECAVA Grupo, Hospital Universitario La Paz, Madrid, Spain
14. King Abdulaziz University, Jeddah, Saudi Arabia
15. Dr. Mohan Diabetes Specialities Centre and Madras Diabetes Research Foundation, Chennai, India
16. Unit of International Health, University of Copenhagen, Copenhagen, Denmark
17. Centre for Public Health Research, KEMRI, Nairobi, Kenya
18. Department of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands
19. Department of General Practice and Elderly Care Medicine and the EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands
20. Department of Internal Medicine and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, the Netherlands
21. IRSA, La Riche, France
22. Department of Medicine, University of Washington, Seattle, WA, USA
23. Department of Anthropology, University of Washington, Seattle, WA, USA
24. Holbaek Hospital, Holbaek, Denmark
25. Seattle Epidemiologic Research and Information Center, VA Puget Sound Health Care System, Seattle, WA, USA
26. Steno Diabetes Center A/S, Gentofte, Denmark - ISSN：1432-0428
文摘
Aims/Hypothesis The relationships between smoking and glycaemic variables have not been well explored. We compared HbA1c, fasting plasma glucose (FPG) and 2h plasma glucose (2H-PG) in current, ex- and never-smokers. Methods This meta-analysis used individual data from 16,886 men and 18,539 women without known diabetes in 12 DETECT-2 consortium studies and in the French Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) and Telecom studies. Means of three glycaemic variables in current, ex- and never-smokers were modelled by linear regression, with study as a random factor. The I 2 statistic was used to evaluate heterogeneity among studies. Results HbA1c was 0.10% (95% CI 0.08, 0.12) (1.1mmol/mol [0.9, 1.3]) higher in current smokers and 0.03% (0.01, 0.05) (0.3mmol/mol [0.1, 0.5]) higher in ex-smokers, compared with never-smokers. For FPG, there was no significant difference between current and never-smokers (0.004mmol/l [0.03, 0.02]) but FPG was higher in ex-smokers (0.12mmol/l [0.09, 0.14]). In comparison with never-smokers, 2H-PG was lower (0.44mmol/l [0.52, 0.37]) in current smokers, with no difference for ex-smokers (0.02mmol/l [0.06, 0.09]). There was a large and unexplained heterogeneity among studies, with I 2 always above 50%; I 2 was little changed after stratification by sex and adjustment for age and BMI. In this study population, current smokers had a prevalence of diabetes that was 1.30% higher as screened by HbA1c and 0.52% lower as screened by 2H-PG, in comparison with never-smokers. Conclusion/interpretation Across this heterogeneous group of studies, current smokers had a higher HbA1c and lower 2H-PG than never-smokers. This will affect the chances of smokers being diagnosed with diabetes.