Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes

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• 作者：Antonysunil Adaikalakoteswari (1)
  Ramamurthy Jayashri (2)
  Nithya Sukumar (1)
  Hema Venkataraman (1)
  Rajendra Pradeepa (2)
  Kuppan Gokulakrishnan (2)
  Ranjit Mohan Anjana (2)
  Philip G McTernan (1)
  Gyanendra Tripathi (1)
  Vinod Patel (3)
  Sudhesh Kumar (1) (4)
  Viswanathan Mohan (2)
  Ponnusamy Saravanan (1) (3) (4)
  
  1. Warwick Medical School ; University of Warwick ; Coventry ; UK
  2. Department of Epidemiology & Diabetology ; Madras Diabetes Research Foundation & Dr.Mohan鈥檚 Diabetes Specialities Centre ; WHO Collaborating Centre for Non-communicable Diseases Prevention and Control & IDF Centre of Education ; 4 ; Conran Smith Road ; Gopalapuram ; Chennai ; 600 086 ; India
  3. Academic department of Diabetes and Metabolism ; George Eliot Hospital ; Nuneaton ; UK
  4. WISDEM centre ; University Hospital Coventry and Warwickshire ; Coventry ; UK
  
• 刊名：Cardiovascular Diabetology
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：13
• 期：1
• 全文大小：483 KB
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• 刊物主题：Diabetes; Angiology; Cardiology;
• 出版者：BioMed Central
• ISSN：1475-2840

文摘

Background Metformin, a standard therapy in type 2 diabetes, reduces vitamin B12 levels. Studies linking low vitamin B12 levels and cardiovascular disease are equivocal and suggest improving B12 levels may help in primary prevention. The role of vitamin B12 deficiency on cardiovascular risk factors, especially in type 2 diabetes has not been explored. The aim of this study is to investigate whether vitamin B12 deficiency in type 2 diabetes patients is associated with cardiovascular risk factors in two different ethnic groups in UK and India. Methods Type 2 diabetes patients from two secondary care diabetic centres (Europeans - UK and Indians - India) were studied. Serum vitamin B12, folate and biochemical parameters were measured. Results The prevalence rates of vitamin B12 deficiency ( Conclusions The prevalence of vitamin B12 deficiency is common in type 2 diabetes patients and is associated with adverse lipid parameters. Type 2 diabetes management guidelines should include the recommendation for regular testing for B12 levels, especially for those on metformin.