Vitamin D Supplementation in Infants With Chronic Congestive Heart Failure

详细信息    查看全文

• 作者：Soad A. Shedeed (1) soadshedeed@gmail.com
• 关键词：Vitamin D &#8211 ; Congestive heart failure &#8211 ; Renin ; angiotensin system cytokines &#8211 ; Tumor necrosis factor ; α
• 刊名：Pediatric Cardiology
• 出版年：2012
• 出版时间：June 2012
• 年：2012
• 卷：33
• 期：5
• 页码：713-719
• 全文大小：178.1 KB
• 参考文献：1. Bodyak N, Ayus JC, Achinger S (2007) Activated vitamin D attenuates left ventricular abnormalities induced by dietary sodium in Dahl salt-sensitive animals. Proc Natl Acad Sci USA 104:16810–16815
  2. Canning MO, Grotenhuis K, de Wit H, Ruwhof C, Drexhage HA (2001) 1-alpha,25-Dihydroxyvitamin D3 (1,25(OH)(2)D(3)) hampers the maturation of fully active immature dendritic cells from monocytes. Eur J Endocrinol 145:351–357
  3. DeVries JE (1995) Immunosuppressive and anti-inflammatory properties of interleukin 10. Ann Med 27:537–541
  4. Hollycross BJ, Judith Radin M (2010) Cytokines in heart failure: potential interactions with angiotensin II and leptin. Mol Interv 5:1543–1546
  5. Kim DH, Sabour S, Sagar UN, Adams S, Whellan DJ (2008) Prevalence of hypovitaminosis D in cardiovascular diseases (from the National Health and Nutrition Examination Survey 2001 to 2004). Am J Cardiol 102:1540–1544
  6. Koller-Strametz J, Pacher R, Frey B, Kos T, Woloszczuk W, Stanek B (1998) Circulating tumor necrosis factor-alpha levels in chronic heart failure: relation to its soluble receptor II, interleukin-6, and neurohumoral variables. J Heart Lung Transpl 17:356–362
  7. Lee JH, O’Keefe JH, Bell D, Hensrud DD, Holick MF (2008) Vitamin D deficiency: an important, common, and easily treatable cardiovascular risk factor? J Am Coll Cardiol 52:1949–1956
  8. Levine M, Nikkanen H, Pallin DJ (2009) The effects of intravenous calcium in patients with digoxin toxicity. J Emerg Med 18:413–417
  9. Rauchhaus M, Doehner W, Francis DP (2000) Plasma cytokine parameters and mortality in patients with chronic heart failure. Circulation 102:3060–3067
  10. Ross RD, Bollinger RO, Pinsky WW (1992) Grading the severity of congestive heart failure in infants. Pediatr Cardiol 13:72–75
  11. Rostand SG, Drueke TB (1999) Parathyroid hormone, vitamin D, and cardiovascular disease in chronic renal failure. Kidney Int 56:383–392
  12. Schleithoff SS, Zittermann A, Tenderich G, Berthold HK, Stehle P, Koerfer R (2006) Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 83:754–759
  13. Snider A, Serwer G, Ritter S (1996) Methods for obtaining quantitative information from echocardiographic examination. In: Snider A, Serwer G, Ritter S (eds) Echocardiography in pediatric heart disease, 2nd edn. Mosby, St. Louis, pp 133–243
  14. Stoddard MF, Pearson AC, Kern MJ (2006) Influence of alteration in preload on the pattern of left ventricular diastolic filling as assessed by Doppler echocardiography in humans. Circulation 79:1226–1236
  15. Tishkoff DX, Nibbelink KA, Holmberg KH, Dandu L, Simpson RU (2008) Functional vitamin D receptor (VDR) in the t-tubules of cardiac myocytes: VDR knockout cardiomyocyte contractility. Endocrinology 149:558–564
  16. Tomar M, Radhakrishnan S, Shrivastava S (2010) Myocardial dysfunction due to hypocalcemia. Indian Pediatr 47:781–783
  17. Wagner CL, Greer FR (2008) American Academy of Pediatrics, Section on Breastfeeding Medicine and Committee on Nutrition. Prevention of rickets and vitamin D deficiency in infants, children, and adolescents: new guidelines for vitamin D intake. Pediatrics 122:1142–1152
  18. Weber KT, Simpson RU, Carbone LD (2008) Vitamin D and calcium dyshomeostasis-associated heart failure. Heart 94:540–541
  19. Zhu Y, Mahon BD, Froicu M, Cantorna MT (2005) Calcium and 1alpha,25-dihydroxyvitamin D3 target the TNF-alpha pathway to suppress experimental inflammatory bowel disease. Eur J Immunol 35:217–224
  20. Zittermann A, Schleithoff SS, Tenderich G, Berthold HK, Korfer R, Stehle P (2003) Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure? J Am Coll Cardiol 41:105–112
• 作者单位：1. Pediatrics Department, Zagazig University, Zagazig, Sharkia Governorate, Egypt
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Cardiology
  Cardiac Surgery
  Vascular Surgery
  
• 出版者：Springer New York
• ISSN：1432-1971

文摘

Increased circulating proinflammatory cytokines may contribute to the pathogenesis of congestive heart failure (CHF). In vitro studies have suggested that vitamin D suppresses proinflammatory cytokines and increases anti-inflammatory cytokines. The aim of this work was to evaluate the effect of vitamin D supplementation on renin-angiotensin system cytokines as well as different clinical, biochemical, and echocardiographic variables in infants with chronic CHF. This was a double-blind, placebo-controlled intervention study and included 80 infants with CHF. The intervention consisted of either giving Vitamin D₃ oral drops (group I) or placebo oral drops (group II). In both study groups, baseline 25-hydroxyvitamin D [25(OH)D] concentrations were below the lower end of the reference range. After 12 weeks of intervention, vitamin D supplementation for group I infants caused significant improvement of HF score, left-ventricular (LV) end-diastolic diameter, LV end-systolic diameter, LV ejection fraction%, and myocardial performance index together with markedly increased serum 25(OH)D and interleukin (IL)-10 and decreased PTH, IL-6, and TNF-α compared with the placebo group; these differences were statistically significant (p < 0.001). Vitamin D supplementation has great benefits as an anti-inflammatory agent in infants with CHF. It helps acceleration of the clinical improvement and cytokine profile balance.