Associations of circulating retinol, vitamin E, and 1,25-dihydroxyvitamin D with prostate cancer diagnosis, stage, and grade

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• 作者：Rebecca Gilbert (1) becky.gilbert@bristol.ac.uk
  Chris Metcalfe (1)
  William D. Fraser (2)
  Jenny Donovan (1)
  Freddie Hamdy (3)
  David E. Neal (4)
  J. Athene Lane (1)
  Richard M. Martin (1)
• 关键词：Prostate cancer &#8211 ; Vitamin D &#8211 ; 1 ; 25 ; Dihydroxyvitamn D &#8211 ; Retinol &#8211 ; Vitamin E
• 刊名：Cancer Causes and Control
• 出版年：2012
• 出版时间：November 2012
• 年：2012
• 卷：23
• 期：11
• 页码：1865-1873
• 全文大小：204.9 KB
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• 作者单位：1. School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS UK2. Norwich Medical School, University of East Anglia, Norwich, UK3. Nuffield Department of Surgery, University of Oxford, Oxford, UK4. Department of Oncology, University of Cambridge, Cambridge, UK
• ISSN：1573-7225

文摘

Purpose Some epidemiological studies suggest that vitamin A (retinol), vitamin E, and vitamin D (total 25-hydroxyvitamin D, 25(OH)D; 1,25-dihydroxyvitamin, 1,25(OH)₂D) are protective against prostate cancer. However, the evidence is not conclusive, with positive and null associations reported for all three vitamins. Limitations of previous studies include small sample size, lack of population controls, and reliance on self-reported dietary intake. Few studies have explored the interactions of circulating 25(OH)D with 1,25(OH)₂D or retinol, which are biologically plausible interactions.