Systematic Review: Insight into Antimalarial Peptide

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• 作者：Shweta Sinha ; Ashutosh Singh ; Bikash Medhi…
• 刊名：International Journal of Peptide Research and Therapeutics
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：22
• 期：3
• 页码：325-340
• 全文大小：594 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Biochemistry
  Animal Anatomy, Morphology and Histology
  Polymer Sciences
  
• 出版者：Springer Netherlands
• ISSN：1573-3904
• 卷排序：22

文摘

Antimalarial peptides varying in size, sequence, charge, conformation and structure, hydrophobicity and amphipathicity reflect their heterogeneity in antimalarial activity. Due to global concern of antimalarial drug resistance, these peptides are seldom in attention for therapeutic values as this microbial and synthetic peptide are likely known for delaying the drug resistance phenomenon. Despite of this, among most of the peptides that have shown activity in cultured parasitized erythrocytes were failing to show its efficacy on in vivo models and few of them that are efficacious are not clinically significant on the host. A systematic literature search was carried out to obtain all related studies in PubMed, EMBASE and GOOGLE SCHOLAR from year 1989 to till date 2015 and we found only 63 studies that focus on antimalarial activity of different peptides originated from different sources under in vitro and in vivo conditions. Antimalarial peptides that are mostly included in this review is the naturally occurring along with their derivatives obtained from different sources ranging from lower prokaryotes to higher eukaryotes. Most of the antimalarial peptides had undergone only in vitro testing on Plasmodium falciparum strains having very less potency, but higher selectivity in comparison to standard drugs. The study included in this article will give future direction for development of more antimalarial peptide with desired efficacy and safety.KeywordsAntimalarial peptideNaturalSyntheticIn vitroIn vivoActivity