Evaluation of Lp-PLA2 mass, vitronectin and PAI-1 activity levels in patients with preeclampsia

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• 作者：?zlem Balc? Ekmek?i ; Hakan Ekmek?i ; Zeynep Güng?r…
• 关键词：Preeclampsia ; Lp ; PLA2 ; PAI ; 1 ; T ; PA ; Vitronectin ; Endothelial dysfunction
• 刊名：Archives of Gynecology and Obstetrics
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：292
• 期：1
• 页码：53-58
• 全文大小：363 KB
• 参考文献：1.ACOG Committee on Obstetric Practice (2002) ACOG practice bulletin. Diagnosis and management of preeclampsi and eclampsia. Number 33, January 2002. American College of Obsteticians and Gynecologists. Int J Gynaecol Obstet 77(1):67-5View Article
  2.Weiss G, Goldsmith LT, Taylor RN, Bellet D, Taylor HS (2009) Inflammation in reproductive disorders. Reprod Sci 16(2):216-29View Article PubMed Central PubMed
  3.Fan P, Liu XH, He GL, Zhang S, Zhang JX, Bai H (2012) Maternal and fetal plasma platelet-activating factor acetylhydrolase activity and distribution in pre-eclampsia. Pediatr Res 72(4):426-31View Article PubMed
  4.Ramma W, Ahmed A (2011) Is inflammation the cause of pre-eclampsia? Biochem Soc Trans 39(6):1619-627View Article PubMed Central PubMed
  5.Dusse LM, Rios DR, Pinheiro MB, Cooper AJ, Lwaleed BA (2011) Pre-eclampsia: relationship between coagulation, fibrinolysis and inflammation. Clin Chim Acta 412(1-):17-1View Article PubMed
  6.Boij R, Svensson J, Nilsson-Ekdahl K, Sandholm K, Lindahl TL, Palonek E, Garle M, Berg G, Ernerudh J, Jenmalm M, Matthiesen L (2012) Biomarkers of coagulation, inflammation, and angiogenesis are independently associated with preeclampsia. Am J Reprod Immunol 68(3):258-70View Article PubMed
  7.Abbate R, Cioni G, Ricci I, Miranda M, Gori AM (2012) Thrombosis and acute coronary syndrome. Thromb Res 129(3):235-40View Article PubMed
  8.Yang EH, McConnell JP, Lennon RJ, Barsness GW, Pumper G, Hartman SJ, Rihal CS, Lerman LO, Lerman A (2006) Lipoprotein-associated phospholipase A2 is an independent marker for coronary endothelial dysfunction in humans. Arterioscler Thromb Vasc Biol 26(1):106-11View Article PubMed
  9.Lavi S, McConnell JP, Rihal CS, Prasad A, Mathew V, Lerman LO, Lerman A (2007) Local production of lipoprotein-associated phospholipase A2 and lysophosphatidylcholine in the coronary circulation: association with early coronary atherosclerosis and endothelial dysfunction in humans. Circulation 115(21):2715-721View Article PubMed
  10.Garg PK, McClelland RL, Jenny NS, Criqui M, Liu K, Polak JF, Jorgensen NW, Cushman M (2011) Association of lipoprotein-associated phospholipase A (2) and endothelial function in the Multi-Ethnic Study of Atherosclerosis (MESA). Vasc Med 16(4):247-52View Article PubMed
  11.Aso Y (2007) Plasminogen activator inhibitor (PAI)-1 in vascular inflammation and thrombosis. Front Biosci 12:2957-966View Article PubMed
  12.Wikstr?m AK, Nash P, Eriksson UJ, Olovsson MH (2009) Evidence of increased oxidative stress and a change in the plasminogen activator inhibitor (PAI)-1 to PAI-2 ratio in early-onset but not late-onset preeclampsia. Am J Obstet Gynecol 201(6):597.e1-97.e8View Article
  13.Ekmek?i OB, Ekmek?i H (2006) Vitronectin in atherosclerotic disease. Clin Chim Acta 368(1-):77-3View Article PubMed
  14.ACOG Committee on Obstetric Practice (2002) ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. Obstet Gynecol 99(1):159-67View Article
  15.Greer IA, Dawes J, Johnston TA, Calder AA (1991) Neutrophil activation is confined to the maternal circulation in pregnancy-induced hypertension. Obstet Gynecol 78(1):28-2PubMed
  16.Lynch AM, Murphy JR, Gibbs RS, Levine RJ, Giclas PC, Salmon JE, Holers VM (2010) The interrelationship of complement-activation fragments and angiogenesis-related factors in early pregnancy and their association with pre-eclampsia. BJOG 117(4):456-62View Article PubMed
  17.Szarka A, Rigó J Jr, Lázár L, Beko G, Molvarec A (2010) Circulating cytokines, chemokines and adhesion molecules in normal pregnancy and preeclampsia determined by multiplex suspension array. BMC Immunol 11:59View Article PubMed Central PubMed
  18.Renckens R, Roelofs JJ, de Waard V, Florquin S, Lijnen HR, Carmeliet P, van der Poll T (2005) The role of plasminogen activator inhibitor type 1 in the inflammatory response to local tissue injury. J Thromb Haemost 3(5):1018-025View Article PubMed
  19.Chappell LC, Seed PT, Briley A, Kelly FJ, Hunt BJ, Charnock-Jones DS, Mallet AI, Poston L (2002) A longitudinal study of biochemical variables in women at risk of preeclampsia. Am J Obstet Gynecol 187(1):127-36View Article PubMed
  20.Tabak O, Gelisgen R, Uzun H, Kalender B, Balci H, Curgunlu A, Simsek G, Karter Y (2009) Hypertension and hemostatic/fibrinolytic balance disorders. Clin Invest Med 32(6):E285–E292PubMed
  21.Tanjung MT, Siddik HD, Hariman H, Koh SC (2005) Coagulation and fibrinolysis in preeclampsia and neonates. Clin Appl Thromb Hemost 11(4):467-73View Article PubMed
  22.Shen J, Ma X, Yi F, Rasul A, Cui M, Ma T (2013) Increased expression levels of vitronectin in the maternal fetal interface of placenta in early-onset severe preeclampsia. Mol Med Rep 7(1):53-8PubMed
  23.Asch E, Podack E (1990) Vitronectin binds to activated human platelets and plays a role in platelet aggregation. J Clin Invest 85(5):1372-378View Article
• 作者单位：?zlem Balc? Ekmek?i (1)
  Hakan Ekmek?i (1) (3)
  Zeynep Güng?r (1)
  Abdullah Tüten (2)
  M. Sait Toprak (1)
  Meltem Korkmaz (1)
  Mahmut ?ncül (2)
  Oktay ?al??kan (1)
  Mine Kucur (1)
  Orkide Donma (1)
  R?za Madazl? (2)
  Hüseyin S?nmez (1)
  
  1. Department of Biochemistry, Cerrahpasa Medical School, University of Istanbul, Istanbul, Turkey
  3. Seyit ?mer Mah. Alt? mermer cad. Alt? mermer ??k. Saray Ap. A Blok. No:2/17 Kocamustafapa?a, Istanbul, Turkey
  2. Department of Obstetrics and Gynecology, Cerrahpasa Medical School, University of Istanbul, Istanbul, Turkey
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Gynecology
  Obstetrics and Perinatology
  Endocrinology
  Human Genetics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0711

文摘

Purpose The aim of the current study is to determine, correlate and compare the plasma lipoprotein-associated phospholipase A2 (Lp-PLA2), vitronectin (Vn), Plasminogen activator inhibitor-1 (PAI-1) activity and tissue plasminogen activator (t-PA) levels in early-onset preeclampsia, late-onset preeclampsia and in control pregnant women. Methods A total of 79 individuals, 30 early-onsets, and 22 late-onset preeclamptic and 27 control pregnant women were included into the scope of this study. Enzyme-linked immunosorbent assay procedure was used to determine the serum Lp-PLA2 and plasma Vn, t-PA antigen and PAI-1 activity levels. Serum C-reactive protein (CRP) levels were measured immunoturbidimetrically in routine clinical chemistry analyser. Results In patients with preeclampsia, Lp-PLA2, PAI-1, t-PA, CRP and blood pressures levels were increased (p?=?0.000) and correlated with each other. Vn levels were decreased (p?=?0.016) but not correlated with other parameters in preeclamptic patients. Conclusion We are of the opinion that increased Lp-PLA2 levels may partially contribute to endothelial dysfunction by the progression of inflammation. In addition, increased complex formation with Vn is likely to bring about the increase of PAI-1 activity in patients with preeclampsia. Moreover, increased t-PA and decreased Vn levels may also be the consequences of compensatory mechanisms against disease progression.