Fibronectin-, vitronectin- and laminin-binding proteins at the cell walls of Candida parapsilosis and Candida tropicalis pathogenic yeasts
详细信息 查看全文
- 作者：Andrzej Kozik ; Justyna Karkowska-Kuleta ; Dorota Zajac ; Oliwia Bochenska…
- 关键词：Non ; albicans Candida species ; Candidiasis ; Extracellular matrix ; Fibronectin ; Vitronectin ; Laminin
- 刊名：BMC Microbiology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：15
- 期：1
- 全文大小：1,004 KB
- 刊物主题：Microbiology; Biological Microscopy; Fungus Genetics; Parasitology; Virology; Life Sciences, general;
- 出版者：BioMed Central
- ISSN：1471-2180
文摘
Background Candida parapsilosis and C. tropicalis increasingly compete with C. albicans—the most common fungal pathogen in humans—as causative agents of severe candidiasis in immunocompromised patients. In contrast to C. albicans, the pathogenic mechanisms of these two non-albicans Candida species are poorly understood. Adhesion of Candida yeast to host cells and the extracellular matrix is critical for fungal invasion of hosts.