Correlation Between Use of Antiretroviral Adherence Devices by HIV-Infected Youth and Plasma HIV RNA and Self-Reported Adherence

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• 作者：Parya Saberi ; Kenneth Mayer ; Eric Vittinghoff ; Sylvie Naar-King
• 关键词：Antiretroviral medication adherence ; Adherence devices ; Youth ; Adolescent ; HIV
• 刊名：AIDS and Behavior
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：19
• 期：1
• 页码：93-103
• 全文大小：210 KB
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  16. MacDonell K, Naar-Ki
• 作者单位：Parya Saberi (1)
  Kenneth Mayer (2)
  Eric Vittinghoff (3)
  Sylvie Naar-King (4)
  The Adolescent Medicine Trials Network for HIV/AIDS Interventions
  
  1. Department of Medicine, University of California, UCSF Box 0886, 50 Beale St., Suite 1300, San Francisco, CA, 94105, USA
  2. Department of Global Health and Population, Harvard School of Public Health, Boston, MA, USA
  3. Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA
  4. Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Public Health
  Health Psychology
  Infectious Diseases
  
• 出版者：Springer Netherlands
• ISSN：1573-3254

文摘

Our objective was to investigate antiretroviral adherence device use by HIV-infected youth and assess associations of device use with viral suppression and self-reported adherence. This cross-sectional, multisite, clinic-based study included data from 1,317 HIV-infected individuals 12-4?years of age that were prescribed antiretroviral therapy. Mean adherence in the past 7 days was 86.1?% and 50.5?% had an undetectable HIV RNA. Pillbox was the most commonly endorsed device. No specific device was independently associated with higher odds of 100?% adherence. Paradoxically, having an undetectable HIV RNA was inversely associated with use of adherence devices (OR 0.80; p?=?0.04); however, among those with p?=?0.003). Our data suggest that adolescents who experienced virologic failure often used adherence devices which may not have been sufficiently effective in optimizing adherence. Therefore, other tailored adherence-enhancing methods need to be considered to maximize virologic suppression and decrease drug resistance and HIV transmission.