Optical Analysis of Zinc Oxide Quantum Dots with Bovine Serum Albumin and Bovine Hemoglobin

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• 作者：Rizwan Wahab (1)
  Sourabh Dwivedi (1)
  Mohd Shahnawaz Khan (2)
  Abdulrahman M. Al-Senaidy (2)
  Hyung-Shik Shin (3)
  Javed Musarrat (4)
  Abdulaziz A. Al-Khedhairy (1)
  
• 关键词：Quantum dots ; Bovine serum albumin ; Bovine hemoglobin ; Circular dichroism
• 刊名：Journal of Pharmaceutical Innovation
• 出版年：2014
• 出版时间：March 2014
• 年：2014
• 卷：9
• 期：1
• 页码：48-52
• 全文大小：488 KB
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• 作者单位：Rizwan Wahab (1)
  Sourabh Dwivedi (1)
  Mohd Shahnawaz Khan (2)
  Abdulrahman M. Al-Senaidy (2)
  Hyung-Shik Shin (3)
  Javed Musarrat (4)
  Abdulaziz A. Al-Khedhairy (1)
  
  1. Department of Zoology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia
  2. Department of Biochemistry, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia
  3. Energy Materials and Surface Science Laboratory, Solar Research Center, School of Chemical Engineering, Chonbuk National University, Jeonju, 561-756, Republic of Korea
  4. Department of Agricultural Microbiology, Faculty of Agricultural Sciences, AMU, Aligarh, 202002, India
  
• ISSN：1939-8042

文摘

Quantum dots (QDs) are widely used in medical, industrial, and household applications owing to their excellent biological property. For its wide medical application, the biocompatibility of QDs is an important aspect of research. The aim of the present study was to synthesize zinc oxide quantum dots (ZnO-QDs) and to investigate the interaction with bovine serum albumin (BSA) and bovine hemoglobin (BHb) using fluorescence quenching method and circular dichroism (CD). The study suggests that the electrostatic force of attraction favors the adsorption of BSA onto ZnO-QDs. The fluorescence quenching of BSA and BHb using QD indicates the formation of QDs-BSA complexes. The CD spectra also showed the changes in secondary structure of proteins by interacting with QDs.