An intraductal papillary neoplasm of the bile duct mimicking a hemorrhagic hepatic cyst: a case report

详细信息    查看全文

• 作者：Tatsuhiko Kakisaka (1)
  Toshiya Kamiyama (1)
  Hideki Yokoo (1)
  Kazuaki Nakanishi (1)
  Kenji Wakayama (1)
  Yosuke Tsuruga (1)
  Hirofumi Kamachi (1)
  Tomoko Mitsuhashi (2)
  Akinobu Taketomi (1)
  
• 关键词：Hemorrhagic hepatic cyst ; Intraductal papillary neoplasm of the bile duct ; Oncocytic
• 刊名：World Journal of Surgical Oncology
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：11
• 期：1
• 全文大小：425KB
• 参考文献：1. Zen Y, Fujii T, Itatsu K, Nakamura K, Minato H, Kasashima S, Kurumaya H, Katayanagi K, Kawashima A, Masuda S, Niwa H, Mitsui T, Asada Y, Miura S, Ohta T, Nakanuma Y: Biliary papillary tumors share pathological features with intraductal papillary mucinous neoplasm of the pancreas. / Hepatology 2006, 44:1333鈥?343. CrossRef
  2. Kim KM, Lee JK, Shin JU, Lee KH, Lee KT, Sung JY, Jang KT, Heo JS, Choi SH, Choi DW, Lim JH: Clinicopathologic features of intraductal papillary neoplasm of the bile duct according to histologic subtype. / Am J Gastroenterol 2012, 107:118鈥?25. CrossRef
  3. Yang J, Wang W, Yan L: The clinicopathological features of intraductal papillary neoplasms of the bile duct in a Chinese population. / Dig Liver Dis 2012, 44:251鈥?56. CrossRef
  4. Kamiyama T, Nakanishi K, Yokoo H, Kamachi H, Tahara M, Yamashita K, Taniguchi M, Shimamura T, Matsushita M, Todo S: Perioperative management of hepatic resection toward zero mortality and morbidity: analysis of 793 consecutive cases in a single institution. / J Am Coll Surg 2010, 211:443鈥?49. CrossRef
  5. Bosman FT, Carneiro F, Hruban RH, Theise ND: / WHO Classification of Tumours of the Digestive System. 4th edition. Lyon: IARC; 2010.
  6. Vilgrain V, Silbermann O, Benhamou JP, Nahum H: MR imaging in intracystic hemorrhage of simple hepatic cysts. / Abdom Imaging 1993, 18:164鈥?67. CrossRef
  7. Hanazaki K, Wakabayashi M, Mori H, Sodeyama H, Yoshizawa K, Yokoyama S, Sode Y, Kawamura N, Miyazaki T: Hemorrhage into a simple liver cyst: diagnostic implications of a recent case. / J Gastroenterol 1997, 32:848鈥?51. CrossRef
  8. Yamaguchi M, Kuzume M, Matsumoto T, Matsumiya A, Nakano H, Kumada K: Spontaneous rupture of a nonparasitic liver cyst complicated by intracystic hemorrhage. / J Gastroenterol 1999, 34:645鈥?48. CrossRef
  9. Hagiwara A, Inoue Y, Shutoh T, Kinoshita H, Wakasa K: Haemorrhagic hepatic cyst: a differential diagnosis of cystic tumour. / Br J Radiol 2001, 74:270鈥?72.
  10. Ishikawa H, Uchida S, Yokokura Y, Iwasaki Y, Horiuchi H, Hiraki M, Kinoshita H, Shirouzu K: Nonparasitic solitary huge liver cysts causing intracystic hemorrhage or obstructive jaundice. / J Hepatobiliary Pancreat Surg 2002, 9:764鈥?68. CrossRef
  11. Kitajima Y, Okayama Y, Hirai M, Hayashi K, Imai H, Okamoto T, Aoki S, Akita S, Gotoh K, Ohara H, Nomura T, Joh T, Yokoyama Y, Itoh M: Intracystic hemorrhage of a simple liver cyst mimicking a biliary cystadenocarcinoma. / J Gastroenterol 2003, 38:190鈥?93. CrossRef
  12. Kanazawa A, Yoshioka Y, Inoi O, Kubo S, Kinoshita H: Intracystic hemorrhage with spontaneous rupture of liver cyst complicated by infection: a case report. / Osaka City Med J 2003, 49:57鈥?0.
  13. Takahashi G, Yoshida H, Mamada Y, Taniai N, Bando K, Tajiri T: Intracystic hemorrhage of a large simple hepatic cyst. / J Nihon Med Sch 2008, 75:302鈥?05. CrossRef
  14. Zhang YL, Yuan L, Shen F, Wang Y: Hemorrhagic hepatic cysts mimicking biliary cystadenoma. / World J Gastroenterol 2009, 15:4601鈥?603. CrossRef
  15. Gaviser D: Solitary nonparasitic cysts of the liver. / Minn Med 1953, 36:831鈥?36. passim
  16. Zen Y, Fujii T, Itatsu K, Nakamura K, Konishi F, Masuda S, Mitsui T, Asada Y, Miura S, Miyayama S, Uehara T, Katsuyama T, Ohta T, Minato H, Nakanuma Y: Biliary cystic tumors with bile duct communication: a cystic variant of intraductal papillary neoplasm of the bile duct. / Mod Pathol 2006, 19:1243鈥?254. CrossRef
  17. Nakanuma Y, Zen Y, Harada K, Ikeda H, Sato Y, Uehara T, Sasaki M: Tumorigenesis and phenotypic characteristics of mucin-producing bile duct tumors: an immunohistochemical approach. / J Hepatobiliary Pancreat Sci 2010, 17:211鈥?22. CrossRef
  18. Horsmans Y, Laka A, Gigot JF, Geubel AP: Serum and cystic fluid CA 19鈥? determinations as a diagnostic help in liver cysts of uncertain nature. / Liver 1996, 16:255鈥?57.
  19. Koffron A, Rao S, Ferrario M, Abecassis M: Intrahepatic biliary cystadenoma: role of cyst fluid analysis and surgical management in the laparoscopic era. / Surgery 2004, 136:926鈥?36. CrossRef
  20. Choi HK, Lee JK, Lee KH, Lee KT, Rhee JC, Kim KH, Jang KT, Kim SH, Park Y: Differential diagnosis for intrahepatic biliary cystadenoma and hepatic simple cyst: significance of cystic fluid analysis and radiologic findings. / J Clin Gastroenterol 2010, 44:289鈥?93. CrossRef
  21. Waanders E, van Keimpema L, Brouwer JT, van Oijen MG, Aerts R, Sweep FC, Nevens F, Drenth JP: Carbohydrate antigen 19鈥? is extremely elevated in polycystic liver disease. / Liver Int 2009, 29:1389鈥?395. CrossRef
  22. Lim JH, Zen Y, Jang KT, Kim YK, Nakanuma Y: Cyst-forming intraductal papillary neoplasm of the bile ducts: description of imaging and pathologic aspects. / AJR Am J Roentgenol 2011, 197:1111鈥?120. CrossRef
  23. Furukawa T, Kl枚ppel G, Volkan Adsay N, Albores-Saavedra J, Fukushima N, Horii A, Hruban RH, Kato Y, Klimstra DS, Longnecker DS, L眉ttges J, Offerhaus GJ, Shimizu M, Sunamura M, Suriawinata A, Takaori K, Yonezawa S: Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study. / Virchows Arch 2005, 447:794鈥?99. CrossRef
  24. Ohtsuka M, Kimura F, Shimizu H, Yoshidome H, Kato A, Yoshitomi H, Furukawa K, Takeuchi D, Takayashiki T, Suda K, Takano S, Kondo Y, Miyazaki M: Similarities and differences between intraductal papillary tumors of the bile duct with and without macroscopically visible mucin secretion. / Am J Surg Pathol 2011, 35:512鈥?21. CrossRef
  25. Jung G, Park KM, Lee SS, Yu E, Hong SM, Kim J: Long-term clinical outcome of the surgically resected intraductal papillary neoplasm of the bile duct. / J Hepatol 2012, 57:787鈥?93. CrossRef
  
• 作者单位：Tatsuhiko Kakisaka (1)
  Toshiya Kamiyama (1)
  Hideki Yokoo (1)
  Kazuaki Nakanishi (1)
  Kenji Wakayama (1)
  Yosuke Tsuruga (1)
  Hirofumi Kamachi (1)
  Tomoko Mitsuhashi (2)
  Akinobu Taketomi (1)
  
  1. Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo, 060-8638, Japan
  2. Department of Surgical Pathology, Hokkaido University Hospital, North 14, West 5, Kita-ku, Sapporo, 060-8648, Japan
  

文摘

An intraductal papillary neoplasm of the bile duct is a biliary, epithelium-lined, cystic lesion that exhibits papillary proliferation and rarely causes large hemorrhagic cystic lesions. Here, we report a case of an intraductal papillary neoplasm of the bile duct mimicking a hemorrhagic hepatic cyst in a middle-aged man with large hemorrhagic hepatic cysts who experienced abdominal pain and repeated episodes of intracystic bleeding. Following portal vein embolization, extended right hepatic lobectomy was performed, and intraoperative cholangiography revealed communication between the intracystic space and the hepatic duct. Although histological studies revealed that the large hemorrhagic lesion was not lined with epithelium, the surrounding multilocular lesions contained biliary-derived epithelial cells that presented as papillary growths without ovarian-like stroma. A diagnosis of oncocytic-type intraductal papillary neoplasm of the bile duct was made, and we hypothesized that intracystic bleeding with denudation of the lining epithelial cells might occur as the cystically dilated bile duct increased in size. Differential diagnosis between a hemorrhagic cyst and a cyst-forming intraductal papillary neoplasm of the bile duct with bleeding is difficult. However, an intraductal papillary neoplasm of the bile duct could manifest as multilocular hemorrhagic lesions; therefore, complete resection should be performed for a better prognosis.