The Oxidative Damage and Disbalance of Calcium Homeostasis in Brain of Chicken Induced by Selenium Deficiency

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• 作者：Shi-Wen Xu (1)
  Hai-Dong Yao (1)
  Jian Zhang (1)
  Zi-Wei Zhang (1)
  Jin-Tao Wang (1)
  Jiu-Li Zhang (1)
  Zhi-Hui Jiang (1)
  
• 关键词：Oxidative damage ; Calcium homeostasis ; Selenium deficiency ; Chicken
• 刊名：Biological Trace Element Research
• 出版年：2013
• 出版时间：February 2013
• 年：2013
• 卷：151
• 期：2
• 页码：225-233
• 全文大小：818KB
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• 作者单位：Shi-Wen Xu (1)
  Hai-Dong Yao (1)
  Jian Zhang (1)
  Zi-Wei Zhang (1)
  Jin-Tao Wang (1)
  Jiu-Li Zhang (1)
  Zhi-Hui Jiang (1)
  
  1. Department of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, People’s Republic of China
  

文摘

Dietary selenium (Se) deficiency can influence the function of the brain. Our objective was to investigate the effects of Se deficiency on oxidative damage and calcium (Ca) homeostasis in brain of chicken. In the present study, 1-day-old chickens were fed either a commercial diet (as control group) with 0.15?mg/kg Se or a Se-deficient diet (as L group) with 0.033?mg/kg Se for 75?days. Then, brain injury biomarkers were examined, including histological analysis, ultrastructure assay, and apoptosis assay. We also examined the effect of Se deficiency on the Se-containing antioxidative enzyme glutathione peroxidase (GSH-Px), the level of glutathione (GSH), and the Ca homeostasis in brain of chicken. The results showed that the levels of Se and GSH and activity of GSH-Px are seriously reduced by 33.8-6?% (P-lt;-.001), 24.51-7.84?% (P-lt;-.001), and 20.70-4.24?% (P-lt;-.01), respectively. In the present study, we also perform histological analysis and ultrastructure assay and find that Se deficiency caused disorganized histological structure, damage to the mitochondria, fusion of nuclear membrane and nucleus shrinkage, higher apoptosis rate (P-lt;-.001), and increase of Ca homeostasis (P-lt;-.05 or P-lt;-.01 or P-lt;-.001) in the brain of chicken. In conclusion, the results demonstrated that Se deficiency induced oxidative damage and disbalance of Ca homeostasis in the brain of chicken. Similar to mammals, chickens brain is also extremely susceptible to oxidative damage and selenium deficiency.