Induction of heme oxygenase-1 by hemin protects lung against orthotopic autologous liver transplantation-induced acute lung injury in rats

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• 作者：Xinjin Chi ; Na Guo ; Weifeng Yao ; Yi Jin ; Wanling Gao…
• 关键词：Heme oxygenase ; 1 ; Acute lung injury ; Inflammation ; Oxidative stress ; Orthotopic autologous liver transplantation
• 刊名：Journal of Translational Medicine
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：14
• 期：1
• 全文大小：3,675 KB
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• 作者单位：Xinjin Chi (1)
  Na Guo (1)
  Weifeng Yao (1)
  Yi Jin (2)
  Wanling Gao (1)
  Jun Cai (1)
  Ziqing Hei (1)
  
  1. Department of Anesthesiology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, Guangdong, China
  2. Department of Pathology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, Guangdong, China
  
• 刊物主题：Biomedicine general; Medicine/Public Health, general;
• 出版者：BioMed Central
• ISSN：1479-5876

文摘

Background Post-liver transplantation acute lung injury (ALI) severely affects patients’ survival, whereas the mechanism is unclear and effective therapy is lacking. The authors postulated that reperfusion-induced increased oxidative stress plays a critical role in mediating post-liver transplantation ALI and that induction of heme oxgenase-1 (HO-1), an enzyme with anti-oxidative stress properties, can confer effective protection of lung against ALI.