Systematic review of fractionated brain metastases radiotherapy

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• 作者：George Rodrigues (1) (2)
  Andrew Warner (1)
  Glenn Bauman (1)
  Suresh Senan (3)
  Frank Lagerwaard (3)
  
• 关键词：Fractionated radiotherapy ; Hypofractionation ; Stereotactic technique ; Systematic review ; Brain metastases
• 刊名：Journal of Radiation Oncology
• 出版年：2014
• 出版时间：March 2014
• 年：2014
• 卷：3
• 期：1
• 页码：29-41
• 全文大小：802 KB
• 参考文献：1. Gaspar LE, Mehta MP, Patchell RA, Burri SH, Robinson PD, Morris RE, Ammirati M, Andrews DW, Asher AL, Cobbs CS, Kondziolka D, Linskey ME, Loeffler JS, McDermott M, Mikkelsen T, Olson JJ, Paleologos NA, Ryken TC, Kalkanis SN (2010) The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol 96:17鈥?2 CrossRef
  2. Kalkanis SN, Kondziolka D, Gaspar LE, Burri SH, Asher AL, Cobbs CS, Ammirati M, Robinson PD, Andrews DW, Loeffler JS, McDermott M, Mehta MP, Mikkelsen T, Olson JJ, Paleologos NA, Patchell RA, Ryken TC, Linskey ME (2010) The role of surgical resection in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol 96:33鈥?3 CrossRef
  3. Linskey ME, Andrews DW, Asher AL, Burri SH, Kondziolka D, Robinson PD, Ammirati M, Cobbs CS, Gaspar LE, Loeffler JS, McDermott M, Mehta MP, Mikkelsen T, Olson JJ, Paleologos NA, Patchell RA, Ryken TC, Kalkanis SN (2009) The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol 96:45鈥?8 CrossRef
  4. Kellner CP, D鈥橝mbrosio AL (2011) Surgical management of brain metastases. Neurosurg Clin N Am 22:53鈥?9 CrossRef
  5. Smith ML, Lee JY (2007) Stereotactic radiosurgery in the management of brain metastasis. Neurosurg Focus 22:E5 CrossRef
  6. Zhang X, Zhang W, Cao WD, Cheng G, Liu B, Cheng J (2012) A review of current management of brain metastases. Ann Surg Oncol 19:1043鈥?050 CrossRef
  7. Mehta MP, Tsao MN, Whelan TJ, Morris DE, Hayman JA, Flickinger JC, Mills M, Rogers CL, Souhami L (2005) The American Society for Therapeutic Radiology and Oncology (ASTRO) evidence-based review of the role of radiosurgery for brain metastases. Int J Radiat Oncol Biol Phys 63:37鈥?6 CrossRef
  8. Andrews DW, Scott CB, Sperduto PW, Flanders AE, Gaspar LE, Schell MC, Werner-Wasik M, Demas W, Ryu J, Bahary JP, Souhami L, Rotman M, Mehta MP, Curran WJ Jr (2004) Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial. Lancet 363:1665鈥?672 CrossRef
  9. Sneed PK, Lamborn KR, Forstner JM, McDermott MW, Chang S, Park E, Gutin PH, Phillips TL, Wara WM, Larson DA (1999) Radiosurgery for brain metastases: is whole brain radiotherapy necessary? Int J Radiat Oncol Biol Phys 43:549鈥?58 CrossRef
  10. Rades D, Schild SE (2012) Do patients with a limited number of brain metastases need whole-brain radiotherapy in addition to radiosurgery? Strahlenther Onkol (in press)
  11. Chang EL, Wefel JS, Hess KR, Allen PK, Lang FF, Kornguth DG, Arbuckle RB, Swint JM, Shiu AS, Maor MH, Meyers CA (2009) Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial. Lancet Oncol 10:1037鈥?044 CrossRef
  12. Bauman G, Yartsev S, Fisher B, Kron T, Laperriere N, Heydarian M, VanDyk J (2007) Simultaneous infield boost with helical tomotherapy for patients with 1 to 3 brain metastases. Am J Clin Oncol 30:38鈥?4 CrossRef
  13. Ikushima H (2010) Radiation therapy: state of the art and the future. J Med Invest 57:1鈥?1 CrossRef
  14. Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol 62:1006鈥?012 CrossRef
  15. Aoki M, Abe Y, Hatayama Y, Kondo H, Basaki K (2006) Clinical outcome of hypofractionated conventional conformation radiotherapy for patients with single and no more than three metastatic brain tumors, with noninvasive fixation of the skull without whole brain irradiation. Int J Radiat Oncol Biol Phys 64:414鈥?18 CrossRef
  16. Aoyama H, Shirato H, Onimaru R, Kagei K, Ikeda J, Ishii N, Sawamura Y, Miyasaka K (2003) Hypofractionated stereotactic radiotherapy alone without whole-brain irradiation for patients with solitary and oligo brain metastasis using noninvasive fixation of the skull. Int J Radiat Oncol Biol Phys 56:793鈥?00 CrossRef
  17. Davey P, Schwartz ML, Scora D, Gardner S, O鈥橞rien PF (2007) Fractionated (split dose) radiosurgery in patients with recurrent brain metastases: implications for survival. Br J Neurosurg 21:491鈥?95 CrossRef
  18. De Salles AA, Hariz M, Bajada CL, Goetsch S, Bergenheim T, Selch M, Holly FE, Solberg T, Becker DP (1993) Comparison between radiosurgery and stereotactic fractionated radiation for the treatment of brain metastases. Acta Neurochir Suppl (Wien) 58:115鈥?18
  19. Fahrig A, Ganslandt O, Lambrecht U, Grabenbauer G, Kleinert G, Sauer R, Hamm K (2007) Hypofractionated stereotactic radiotherapy for brain metastases鈥攔esults from three different dose concepts. Strahlenther Onkol 183:625鈥?30 CrossRef
  20. Higuchi Y, Serizawa T, Nagano O, Matsuda S, Ono J, Sato M, Iwadate Y, Saeki N (2009) Three-staged stereotactic radiotherapy without whole brain irradiation for large metastatic brain tumors. Int J Radiat Oncol Biol Phys 74:1543鈥?548 CrossRef
  21. Ikushima H, Tokuuye K, Sumi M, Kagami Y, Murayama S, Ikeda H, Tanaka M, Oyama H, Shibui S, Nomura K (2000) Fractionated stereotactic radiotherapy of brain metastases from renal cell carcinoma. Int J Radiat Oncol Biol Phys 48:1389鈥?393 CrossRef
  22. Jyothirmayi R, Saran FH, Jalali R, Perks J, Warrington AP, Traish D, Ashley S, Hines F, Brada M (2001) Stereotactic radiotherapy for solitary brain metastases. Clin Oncol (R Coll Radiol) 13:228鈥?34
  23. Kim YJ, Cho KH, Kim JY, Lim YK, Min HS, Lee SH, Kim HJ, Gwak HS, Yoo H, Lee SH (2011) Single-dose versus fractionated stereotactic radiotherapy for brain metastases. Int J Radiat Oncol Biol Phys 81:483鈥?89 CrossRef
  24. Kwon KY, Kong DS, Lee JI, Nam DH, Park K, Kim JH (2007) Outcome of repeated radiosurgery for recurrent metastatic brain tumors. Clin Neurol Neurosurg 109:132鈥?37 CrossRef
  25. Laing RW, Warrington AP, Hines F, Graham JD, Brada M (1993) Fractionated stereotactic external beam radiotherapy in the management of brain metastases. Eur J Cancer 29A:1387鈥?391 CrossRef
  26. Lederman G, Wronski M, Fine M (2001) Fractionated radiosurgery for brain metastases in 43 patients with breast carcinoma. Breast Cancer Res Treat 65:145鈥?54 CrossRef
  27. Lindvall P, Bergstr枚m P, L枚froth PO, Tommy BA (2009) A comparison between surgical resection in combination with WBRT or hypofractionated stereotactic irradiation in the treatment of solitary brain metastases. Acta Neurochir (Wien) 151:1053鈥?059 CrossRef
  28. Lindvall P, Bergstr枚m P, L枚froth PO, Henriksson R, Bergenheim AT (2005) Hypofractionated conformal stereotactic radiotherapy alone or in combination with whole-brain radiotherapy in patients with cerebral metastases. Int J Radiat Oncol Biol Phys 61:1460鈥?466 CrossRef
  29. Marchetti M, Milanesi I, Falcone C, De Santis M, Fumagalli L, Brait L, Bianchi L, Fariselli L (2011) Hypofractionated stereotactic radiotherapy for oligometastases in the brain: a single-institution experience. Neurol Sci 32:393鈥?99 CrossRef
  30. Mariya Y, Sekizawa G, Matsuoka Y, Seki H, Sugawara T, Sasaki Y (2011) Repeat stereotactic radiosurgery in the management of brain metastases from non-small cell lung cancer. Tohoku J Exp Med 223:125鈥?31 CrossRef
  31. Nakayama H, Tokuuye K, Komatsu Y, Ishikawa H, Shiotani S, Nakada Y, Akine Y (2004) Stereotactic radiotherapy for patients who initially presented with brain metastases from non-small cell carcinoma. Acta Oncol 43:736鈥?39 CrossRef
  32. Narayana A, Chang J, Yenice K, Chan K, Lymberis S, Brennan C, Gutin PH (2007) Hypofractionated stereotactic radiotherapy using intensity-modulated radiotherapy in patients with one or two brain metastases. Stereotact Funct Neurosurg 85:82鈥?7 CrossRef
  33. Saitoh J, Saito Y, Kazumoto T, Kudo S, Ichikawa A, Hayase N, Kazumoto K, Sakai H, Shibuya K (2010) Therapeutic effect of linac-based stereotactic radiotherapy with a micro-multileaf collimator for the treatment of patients with brain metastases from lung cancer. Jpn J Clin Oncol 40:119鈥?24 CrossRef
  34. Shirato H, Takamura A, Tomita M, Suzuki K, Nishioka T, Isu T, Kato T, Sawamura Y, Miyamachi K, Abe H, Miyasaka K (1997) Stereotactic irradiation without whole-brain irradiation for single brain metastasis. Int J Radiat Oncol Biol Phys 37:385鈥?91 CrossRef
  35. Tokuuye K, Akine Y, Sumi M, Kagami Y, Murayama S, Nakayama H, Ikeda H, Tanaka M, Shibui S, Nomura K (1998) Fractionated stereotactic radiotherapy of small intracranial malignancies. Int J Radiat Oncol Biol Phys 42:989鈥?94 CrossRef
  36. Tomita N, Kodaira T, Tachibana H, Nakamura T, Nakahara R, Inokuchi H, Shibamoto Y (2008) Helical tomotherapy for brain metastases: dosimetric evaluation of treatment plans and early clinical results. Technol Cancer Res Treat 7:417鈥?24
  37. Vargo JA, Plants BA, Mihailidis DN, Mallah J, Plants M, Welch CA, Clark GM, Farinash LJ, Raja P, Harmon MB, Whaley LA (2011) Early clinical outcomes for 3 radiation techniques for brain metastases: focal versus whole-brain. Pract Radiat Oncol 1:261鈥?70 CrossRef
  38. Assouline A, Levy A, Chargari C, Lamproglou I, Mazeron JJ, Krzisch C (2011) Whole brain radiotherapy: prognostic factors and results of a radiation boost delivered through a conventional linear accelerator. Radiother Oncol 99:214鈥?17 CrossRef
  39. Edwards AA, Keggin E, Plowman PN (2010) The developing role for intensity-modulated radiation therapy (IMRT) in the non-surgical treatment of brain metastases. Br J Radiol 83:133鈥?36 CrossRef
  40. Epstein BE, Scott CB, Sause WT, Rotman M, Sneed PK, Janjan NA, Davis LW, Selim H, Mohiuddin M, Wasserman TH et al (1993) Improved survival duration in patients with unresected solitary brain metastasis using accelerated hyperfractionated radiation therapy at total doses of 54.4 gray and greater. Results of Radiation Therapy Oncology Group 85鈥?8. Cancer 71:1362鈥?367 CrossRef
  41. Giubilei C, Ingrosso G, D鈥橝ndrea M, Benassi M, Santoni R (2009) Hypofractionated stereotactic radiotherapy in combination with whole brain radiotherapy for brain metastases. J Neurooncol 91:207鈥?12 CrossRef
  42. Hoskin PJ, Crow J, Ford HT (1990) The influence of extent and local management on the outcome of radiotherapy for brain metastases. Int J Radiat Oncol Biol Phys 19:111鈥?15 CrossRef
  43. Kim HJ, Hong S, Kim S, Kim JH, Chie EK, Kim IH, Park CI, Ha SW, Wu HG, Kim DG, Kang WS (2003) Efficacy of whole brain radiotherapy combined with fractionated stereotactic radiotherapy in metastatic brain tumors, and prognostic factors. Radiat Med 21:155鈥?60
  44. L茅vy A, Chargari C, Lamproglou I, Mazeron JJ, Krzisch C, Assouline A (2011) Whole brain radiation with supplementary boost for patients for unique brain metastasis from a primitive lung cancer. Cancer Radiother 15:426鈥?29 CrossRef
  45. Manning MA, Cardinale RM, Benedict SH, Kavanagh BD, Zwicker RD, Amir C, Broaddus WC (2000) Hypofractionated stereotactic radiotherapy as an alternative to radiosurgery for the treatment of patients with brain metastases. Int J Radiat Oncol Biol Phys 47:603鈥?08 CrossRef
  46. Murray KJ, Scott C, Greenberg HM, Emami B, Seider M, Vora NL, Olson C, Whitton A, Movsas B, Curran W (1997) A randomized phase III study of accelerated hyperfractionation versus standard in patients with unresected brain metastases: a report of the Radiation Therapy Oncology Group (RTOG) 9104. Int J Radiat Oncol Biol Phys 39:571鈥?74 CrossRef
  47. Rodrigues G, Yartsev S, Yaremko B, Perera F, Dar AR, Hammond A, Lock M, Yu E, Ash R, Caudrelier JM, Khuntia D, Bailey L, Bauman G (2011) Phase I trial of simultaneous in-field boost with helical tomotherapy for patients with one to three brain metastases. Int J Radiat Oncol Biol Phys 80:1128鈥?133 CrossRef
  48. Rodrigues G, Eppinga W, Lagerwaard F, de Haan P, Haasbeek C, Perera F, Slotman B, Yaremko B, Yartsev S, Bauman G (2012) A pooled analysis of arc-based image-guided simultaneous integrated boost radiation therapy for oligometastatic brain metastases. Radiother Oncol 102:180鈥?86 CrossRef
  49. Rodrigus P, de Brouwer P, Raaymakers E (2001) Brain metastases and non-small cell lung cancer. Prognostic factors and correlation with survival after irradiation. Lung Cancer 32:129鈥?36 CrossRef
  50. Sause WT, Scott C, Krisch R, Rotman M, Sneed PK, Janjan N, Davis L, Curran W, Choi KN, Selim H et al (1993) Phase I/II trial of accelerated fractionation in brain metastases RTOG 85-28. Int J Radiat Oncol Biol Phys 26:653鈥?57 CrossRef
  51. Shiau C-Y, Sneed PK, Shu H-K et al (1997) Radiosurgery for brain metastases: relationship of dose and pattern of enhancement to local control. Int J Radiat Oncol Biol Phys 37:375鈥?83 CrossRef
  52. Rodrigues G, Yartsev S, Tay KY, Pond GR, Lagerwaard F, Bauman G (2012) A phase II multi-institutional study assessing simultaneous in-field boost helical tomotherapy for 1鈥? brain metastases. Radiat Oncol 7:42 CrossRef
  
• 作者单位：George Rodrigues (1) (2)
  Andrew Warner (1)
  Glenn Bauman (1)
  Suresh Senan (3)
  Frank Lagerwaard (3)
  
  1. Department of Radiation Oncology, London Regional Cancer Program, London Health Sciences Centre, A3-808 790 Commissioners Rd. E, London, ON, Canada, N6A4L6
  2. Department of Epidemiology and Biostatistics, University of Western Ontario, London, ON, Canada, N6A3K7
  3. Department of Radiation Oncology, VU University Medical Center, de Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
  
• ISSN：1948-7908

文摘

Management of brain metastases includes approaches such as fractionated whole brain radiotherapy (WBRT) and single-fraction stereotactic radiosurgery (SRS). Focal, fractionated radiotherapy given alone or in conjunction with WBRT is a potential alternative to radiosurgery that has been explored in the medical literature. Such fractionation carries theoretical radiobiologic advantages by exploiting cell reassortment and reoxygenation. Integration of image-guided radiation therapy and intensity-modulated radiation therapy can provide an accurate, precise, and conformal treatment platform to provide radiosurgery-like dose escalation without the use of invasive stereotactic fixation devices. The use of the simultaneous in-field radiotherapy technique integrating WBRT with contemporaneous treatment of the boost volume can yield important planning and treatment efficiencies. At the same time, the relative efficacy of fractionated lesional boosts compared with other forms of lesional treatment intensification is unclear. The aim of this systematic review is to determine the clinical benefits and toxicity related to fractionated focal brain radiotherapy for lesional dose escalation in accordance with PRISMA guidelines. Review of the literature for lesional dose escalation, with or without sequential/integrated WBRT, suggests the potential for important clinical benefits including overall survival, local control and acceptable toxicity. In general, such approaches provide clinical benefits competitive with traditional radiosurgery approaches, provided that adequate biological equivalent doses are used. However, given the heterogeneity associated with these reports as well as the retrospective nature of most of the published literature, no firm conclusions regarding the clinical indications of such therapy over traditional SRS or WBRT techniques can be made at this time.