Comparative distribution of complex fractionated atrial electrograms, high dominant frequency (HDF) sites during atrial fibrillation and HDF sites during sinus rhythm
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- 作者：Masayoshi Kofune (1)
Yasuo Okumura (1)
Ichiro Watanabe (1)
Koichi Nagashima (1)
Kazumasa Sonoda (1)
Hiroaki Mano (1)
Rikitake Kogawa (1)
Naoko Sasaki (1)
Kimie Ohkubo (1)
Toshiko Nakai (1)
Mizuki Nikaido (2)
Atsushi Hirayama (1) - 关键词：Complex fractionated atrial electrogram ; Dominant frequency ; Sinus rhythm ; Atrial fibrillation
- 刊名：Journal of Interventional Cardiac Electrophysiology
- 出版年：2013
- 出版时间：April 2013
- 年：2013
- 卷：36
- 期：3
- 页码：297-306
- 全文大小：605KB
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Yasuo Okumura (1)
Ichiro Watanabe (1)
Koichi Nagashima (1)
Kazumasa Sonoda (1)
Hiroaki Mano (1)
Rikitake Kogawa (1)
Naoko Sasaki (1)
Kimie Ohkubo (1)
Toshiko Nakai (1)
Mizuki Nikaido (2)
Atsushi Hirayama (1)
1. Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Ohyaguchi-kamicho, Itabashi-ku, Tokyo, Japan, 173-8610
2. Nihon Kohden Corporation, Tokyo, Japan - ISSN：1572-8595
文摘
Purpose Complex fractionated atrial electrograms (CFAEs) and high dominant frequency sites during atrial fibrillation (AF-HDF) are related to the maintenance of atrial fibrillation (AF). HDF sites in sinus rhythm (SR-HDF; as defined by frequencies of >70?Hz) are suggested to be abnormal atrial tissue. Relations between these electrophysiologic signals have not been elucidated. Methods We investigated the relations between SR-HDF and CFAE and AF-HDF sites during AF. NavX-based maps of CFAE and left atrium (LA)/pulmonary vein (PV) dominant frequency (DF) during AF and DF maps during SR were created for 23 patients with AF (paroxysmal AF (PAF), n--4; persistent AF (PerAF), n--). Results The extent of overlap between SR-HDF and CFAE sites was 51?±-8?% (as calculated by the LA/PV segments containing both an SR-HDF site and a CFAE site/total LA/PV segments containing an CFAE site) and the extent of overlap between SR-HDF and AF-HDF sites was 50?±-5?% (P--.7464). However, statistically poor agreement was noted for both (kappa values, 0.07?±-.19 and 0.08?±-.24, P--.8794). The extent of overlap did not differ between PAF and PerAF patients (SR-HDF and CFAE, 52?% (interquartile range (IQR), 42-9) versus 57?% (IQR, 33-7), P--.5842; SR-HDF and AF-HDF, 43?% (IQR, 25-5) versus 55?% (IQR, 13-3), P--.9465). The bipolar voltage amplitudes of SR-HDF, CFAE, and AF-HDF sites revealed normal voltage areas (1.6?mV (IQR, 0.8-.7), 1.9?mV (IQR, 1.1-.8), and 1.5?mV (IQR, 1.7-.7), respectively). Conclusions In both PAF and PerAF, most CFAE and AF-HDF sites did not correspond to the SR-HDF sites or low-voltage area during SR. Thus, most CFAE and DF signals during AF represent functional electrical activities rather than structural remodeling of the atria.