Calcitonin substitution in calcitonin deficiency reduces particle-induced osteolysis

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• 作者：Max D Kauther (1) (2)
  Hagen S Bachmann (3)
  Laura Neuerburg (2)
  Martina Broecker-Preuss (4)
  Gero Hilken (5)
  Florian Grabellus (6)
  Gabriele Koehler (7)
  Marius von Knoch (2) (8)
  Christian Wedemeyer (2)
  
• 刊名：BMC Musculoskeletal Disorders
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：12
• 期：1
• 全文大小：640KB
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  41. The pre-publication history for this paper can be accessed here:central.com/1471-2474/12/186/prepub" class="a-plus-plus">http://www.biomedcentral.com/1471-2474/12/186/prepub
  
• 作者单位：Max D Kauther (1) (2)
  Hagen S Bachmann (3)
  Laura Neuerburg (2)
  Martina Broecker-Preuss (4)
  Gero Hilken (5)
  Florian Grabellus (6)
  Gabriele Koehler (7)
  Marius von Knoch (2) (8)
  Christian Wedemeyer (2)
  
  1. Department of Trauma Surgery, University Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany
  2. Department of Orthopaedics, University Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany
  3. Institute of Pharmacogenetics, University Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany
  4. Department of Endocrinology, Division of Clinical Chemistry and Laboratory Medicine, University Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Germany
  5. Central Animal Laboratory, University of Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Germany
  6. Institute of Pathology and Neuropathology, University of Duisburg-Essen, Hufelandstra脽e 55, 45122, Essen, Germany
  7. Institute of Pathology, University of M眉nster, Domagkstra脽e 5, 48149, M眉nster, Germany
  8. Department of Orthopaedic Surgery, Klinikum Bremerhaven, Postbrookstr. 103, 27574, Bremerhaven, Germany
  

文摘

Background Periprosthetic osteolysis is a major cause of aseptic loosening in joint arthroplasty. This study investigates the impact of CT (calcitonin) deficiency and CT substitution under in-vivo circumstances on particle-induced osteolysis in Calca -/- mice. Methods We used the murine calvarial osteolysis model based on ultra-high molecular weight polyethylene (UHMWPE) particles in 10 C57BL/6J wild-type (WT) mice and twenty Calca -/- mice. The mice were divided into six groups: WT without UHMWPE particles (Group 1), WT with UHMWPE particles (Group 2), Calca -/- mice without UHMWPE particles (Group 3), Calca -/- mice with UHMWPE particles (Group 4), Calca -/- mice without UHMWPE particles and calcitonin substitution (Group 5), and Calca -/- mice with UHMWPE particle implantation and calcitonin substitution (Group 6). Analytes were extracted from serum and urine. Bone resorption was measured by bone histomorphometry. The number of osteoclasts was determined by counting the tartrate-resistant acid phosphatase (TRACP) + cells. Results Bone resorption was significantly increased in Calca -/- mice compared with their corresponding WT. The eroded surface in Calca -/- mice with particle implantation was reduced by 20.6% after CT substitution. Osteoclast numbers were significantly increased in Calca -/- mice after particle implantation. Serum OPG (osteoprotegerin) increased significantly after CT substitution. Conclusions As anticipated, Calca -/- mice show extensive osteolysis compared with wild-type mice, and CT substitution reduces particle-induced osteolysis.