Expression of heat shock protein gp96 in osteosarcoma and its clinical significance
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- 作者：Weichun Guo (1) (2)
Anmin Chen (1) - 关键词：osteosarcoma ; heat shock protein gp96 ; immunohistochemistry
- 刊名：Frontiers of Medicine
- 出版年：2008
- 出版时间：June 2008
- 年：2008
- 卷：2
- 期：2
- 页码：200-203
- 全文大小：192KB
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Anmin Chen (1)
1. Department of Orthopaedics, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430030, China
2. Department of Orthopaedics, Renmin Hospital of Wuhan University, Wuhan, 430060, China
文摘
This study aims to detect the expression of heat shock protein gp96 (HSPgp96) in osteosarcoma and explore its role in anti-tumor immunity. Expression of HSPgp96 in 45 cases of osteosarcoma, including 24 cases of the osteoblast type, 21 cases of chondroblast type and 5 cases of normal bone tissue were detected by immuno-histochemistry (IHC). The expression rate of HSPgp96 was 100% (45/45) in osteosarcoma, compared with 20% (1/5) in normal bone tissue. The average positive cell rates were 97.23% and 0.48% in osteosarcoma and normal bone tissue, respectively, and the difference between them was significant (P < 0.01). The positive cell rates in osteoblast type and chondroblast type were 97.78% and 96.56%, respectively, and the difference had no statistical significance (P > 0.05). The expression degree of HSPgp96 in osteosarcoma had a clear correlation with the pathologic degree (P < 0.05), while it had no relationship with the clinical stage (P > 0.05). The expression of HSPgp96 is high in osteosarcoma and it may be a significant index for judgment of malignancy degree and an important target site of anti-tumor immunity.