Hesperetin induces the apoptosis of hepatocellular carcinoma cells via mitochondrial pathway mediated by the increased intracellular reactive oxygen species, ATP and calcium

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• 作者：Jixiang Zhang ; Jia Song ; Dandan Wu ; Jing Wang ; Weiguo Dong
• 关键词：Hesperetin ; Apoptosis ; Hepatic carcinoma ; Mitochondria ; Reactive oxygen species
• 刊名：Medical Oncology
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：32
• 期：4
• 全文大小：5,865 KB
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• 刊物主题：Oncology; Hematology; Pathology; Internal Medicine;
• 出版者：Springer US
• ISSN：1559-131X

文摘

Hesperetin, a flavonoid from citrus fruits, has been proved to possess biological activity on various types of human cancers. However, few related studies on hepatocellular carcinoma are available. In this study, we aimed to investigate the effect of hesperetin on hepatocellular carcinoma cells in vitro and in vivo and clarify its potentially specific mechanism. Compared with the control group, the proliferations of hepatocellular carcinoma cells in hesperetin groups were significantly inhibited (P?2O2 (1?mM) or N-acetyl-l-cysteine (5?mM), the inhibition of cell viability by hesperetin was enhanced or reduced, respectively (P?2+ changed in different groups (P?P?Bax and a decrease in that of Bcl-2, mitochondrial AIF, mitochondrial Apaf-1 and mitochondrial Cyt C (P?2+.