Preoperative neutrophil-to-lymphocyte ratio predicts response to first-line platinum-based chemotherapy and prognosis in serous ovarian cancer

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• 作者：Ying Wang ; Ping Liu ; Yan Xu ; Weihao Zhang…
• 关键词：Neutrophil ; to ; lymphocyte ratio ; Serous ovarian cancer ; Chemotherapeutic sensitivity ; Prognosis
• 刊名：Cancer Chemotherapy and Pharmacology
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：75
• 期：2
• 页码：255-262
• 全文大小：437 KB
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  14. Cho H, Hur HW, Kim SW, Kim
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Cancer Research
  Pharmacology and Toxicology
  Oncology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0843

文摘

Purpose To investigate the role of preoperative neutrophil-to-lymphocyte ratio (NLR) in prediction of response to first-line platinum-based chemotherapy and survival outcome in serous ovarian cancer (SOC) patients. Methods Clinicopathologic data were reviewed for patients with SOC treated with primary cytoreduction followed by platinum-based chemotherapy. The correlations of NLR value with clinicopathological features, clinical response to chemotherapy, and survival outcome were further explored. Results High preoperative NLR was significantly associated with advanced FIGO stage, histological grade, increased serum CA-125 level, and positive lymph node metastasis (P?P?=?0.002) and OS (HR 3.254, 95?% CI 1.741-.084; P? Conclusions Our findings indicated that high levels of preoperative NLR might be a potential biomarker of worse response to first-line platinum-based chemotherapy and poor clinical outcomes in patients with SOC. Further validation of this easily available parameter as a potential stratification tool in prospective studies should be encouraged.