Serum Biomarkers of Keshan Disease Assessed Using a Protein Profiling Approach Based on ClinProt Technique

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• 作者：YouZhang Xiang (1)
  Qun Xu (2)
  WuHong Tan (3)
  ShuLan He (3)
  XiaoWei Shi (3)
  WenMing Zhang (1)
  Jing Wang (1)
  XiuHong Wang (1)
  WeiJuan Ma (3)
  
• 关键词：Keshan disease (KD) ; Idiopathic dilated cardiomyopathy (IDCM) ; ClinProt ; Serum biomarkers
• 刊名：The Protein Journal
• 出版年：2014
• 出版时间：August 2014
• 年：2014
• 卷：33
• 期：4
• 页码：344-353
• 全文大小：605 KB
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• 作者单位：YouZhang Xiang (1)
  Qun Xu (2)
  WuHong Tan (3)
  ShuLan He (3)
  XiaoWei Shi (3)
  WenMing Zhang (1)
  Jing Wang (1)
  XiuHong Wang (1)
  WeiJuan Ma (3)
  
  1. Shandong Institute for Endemic Disease Control, Number 11 Yan Dong Xin Road, Jinan, 250014, Shandong, People鈥檚 Republic of China
  2. Blood Center of Shandong Province, Jinan, Shandong Province, People鈥檚 Republic of China
  3. Key Laboratories of Environment and Genes Related to Diseases, Xi鈥檃n Jiaotong University, Xi鈥檃n, Shaanxi, People鈥檚 Republic of China
  
• ISSN：1573-4943

文摘

The etiology of Keshan disease (KD), an endemic myocardiopathy in regions of China, is largely unknown. To show the protein changes in serum from KD patients versus controls and idiopathic dilated cardiomyopathy (IDCM) and to search specific biological markers for differential diagnosis for KD. Serum of 65 patients with KD was compared with 29 patients with IDCM, 62 controls from KD areas and 28 controls from non-KD areas by ClinProt/MALDI-ToF technique. The genetic algorithm, quick classifier algorithm and supervised neural network algorithm methods were used to screen marker proteins and establish diagnostic model. Thirty-four differential peaks were identified in KD patients compared with the healthy controls from non-KD areas. Thirty-eight differentially peaks were identified in KD patients and controls from KD areas; and sixty-seven differentially peaks were identified in patients with KD and patients with IDCM. We believe that marker protein peaks screened in KD patients, healthy controls and IDCM patients may provide clues for the differential diagnosis and treatment of KD.