In situ forming chitosan-based hydrogel as a lung sealant for biological lung volume reduction

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• 作者：Titima Songkroh ; Hongguo Xie ; Weiting Yu ; Guojun Lv ; Xiudong Liu…
• 关键词：Chitosan ; based hydrogels ; Biological lung volume reduction ; Lung sealants ; Emphysema
• 刊名：Chinese Science Bulletin
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：60
• 期：2
• 页码：235-240
• 全文大小：576 KB
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• 刊物主题：Science, general; Life Sciences, general; Physics, general; Chemistry/Food Science, general; Earth Sciences, general; Engineering, general;
• 出版者：Springer Berlin Heidelberg
• ISSN：1861-9541

文摘

Biological lung volume reduction (BLVR) using lung sealant has received more attention recently as a new non-surgical approach to emphysema treatment. Many tissue sealants have been studied but only a few have been proposed for BLVR. In this work, we prepared in situ forming chitosan-based hydrogels (CSG) using covalent cross-linking of chitosan and genipin in the cooperation of ionic interaction between chitosan and sodium orthophosphate hydrate (Na3sub>PO4sub>·12H2sub>O) and characterized by Fourier transform infrared spectroscopy, scanning electron microscopy and rheological methods. CSG showed short gelation time (8?min), high swelling ratio (>100?%) and non-toxicity (3T3 mouse fibroblast cell viability >80?%) under physiological conditions. The application of lung sealant for BLVR was tested in a Chinese dog and evaluated by chest computed tomography. After 3?weeks of the installation of CSG in bronchopulmonary segment, the gel formation was detected at a localized region of bronchi and the local atelectasis occurred. Our findings indicate that this chitosan-based hydrogel is a promising new candidate for use as a lung sealant for BLVR.