Wild chrysanthemum extract prevents UVB radiation-induced acute cell death and photoaging

详细信息    查看全文

• 作者：Sujiao Sun ; Ping Jiang ; Weiting Su ; Yang Xiang ; Jian Li ; Lin Zeng…
• 关键词：Wild chrysanthemum ; Chrysanthemum indicum L ; Ultraviolet ; Cell death ; Photoaging ; Anti ; oxidant
• 刊名：Cytotechnology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：68
• 期：2
• 页码：229-240
• 全文大小：2,803 KB
• 参考文献：Autier P (2009) Sunscreen abuse for intentional sun exposure. Br J Dermatol 161:40–45. doi:10.​1111/​j.​1365-2133.​2009.​09448.​x CrossRef
  Bayerl C, Taake S, Moll I, Jung EG (1995) Characterization of sunburn cells after exposure to ultraviolet light. Photodermatol Photoimmunol Photomed 11(4):149–154
  Cagnol S, Chambard JC (2009) ERK and cell death: mechanisms of ERK-induced cell death–apoptosis, autophagy and senescence. FEBS J 277:2–21. doi:10.​1111/​j.​1742-4658.​2009.​07366.​x CrossRef
  Caricchio R, McPhie L, Cohen PL (2003) Ultraviolet B radiation-induced cell death: critical role of ultraviolet dose in inflammation and lupus autoantigen redistribution. J Immunol 171:5778–5786CrossRef
  Chen W, Bowden GT (1999) Activation of p38 MAP kinase and ERK are required for ultraviolet-B induced c-fos gene expression in human keratinocytes. Oncogene 18:7469–7476. doi:10.​1038/​sj.​onc.​1203210 CrossRef
  Chen W, Tang Q, Gonzales MS, Bowden GT (2001) Role of p38 MAP kinases and ERK in mediating ultraviolet-B induced cyclooxygenase-2 gene expression in human keratinocytes. Oncogene 20:3921–3926. doi:10.​1038/​sj.​onc.​1204530 CrossRef
  Cheon MS, Yoon T, do Lee Y, Choi G, Moon BC, Lee AY, Choo BK, Kim HK (2009) Chrysanthemum indicum Linne extract inhibits the inflammatory response by suppressing NF-kappaB and MAPKs activation in lipopolysaccharide-induced RAW 264.7 macrophages. J Ethnopharmacol 122:473–477. doi:10.​1016/​j.​jep.​2009.​01.​034 CrossRef
  Deacon K, Mistry P, Chernoff J, Blank JL, Patel R (2003) p38 Mitogen-activated protein kinase mediates cell death and p21-activated kinase mediates cell survival during chemotherapeutic drug-induced mitotic arrest. Mol Biol Cell 14:2071–2087. doi:10.​1091/​mbc.​E02-10-0653 CrossRef
  Green A, Williams G, Neale R, Hart V, Leslie D, Parsons P, Marks GC, Gaffney P, Battistutta D, Frost C, Lang C, Russell A (1999) Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomised controlled trial. Lancet 354:723–729. doi:10.​1016/​S0140-6736(98)12168-2 CrossRef
  Green AC, Williams GM, Logan V, Strutton GM (2011) Reduced melanoma after regular sunscreen use: randomized trial follow-up. J Clin Oncol 29:257–263. doi:10.​1200/​JCO.​2010.​28.​7078 CrossRef
  Gutierrez-Uzquiza A, Arechederra M, Bragado P, Aguirre-Ghiso JA, Porras A (2012) p38alpha mediates cell survival in response to oxidative stress via induction of antioxidant genes: effect on the p70S6 K pathway. J Biol Chem 287:2632–2642. doi:10.​1074/​jbc.​M111.​323709 CrossRef
  He YY, Huang JL, Block ML, Hong JS, Chignell CF (2005) Role of phagocyte oxidase in UVA-induced oxidative stress and apoptosis in keratinocytes. J Invest Dermatol 125(3):560–566
  Hildesheim J, Awwad RT, Fornace AJ Jr (2004) p38 Mitogen-activated protein kinase inhibitor protects the epidermis against the acute damaging effects of ultraviolet irradiation by blocking apoptosis and inflammatory responses. J Invest Dermatol 122:497–502. doi:10.​1111/​j.​1523-1747.​2004.​22229.​x CrossRef
  Ichihashi M, Ahmed NU, Budiyanto A, Wu A, Bito T, Ueda M, Osawa T (2000) Preventive effect of antioxidant on ultraviolet-induced skin cancer in mice. J Dermatol Sci 23:S45–S50CrossRef
  Ichihashi M, Ueda M, Budiyanto A, Bito T, Oka M, Fukunaga M, Tsuru K, Horikawa T (2003) UV-induced skin damage. Toxicology 189:21–39CrossRef
  Jeong SC, Kim SM, Jeong YT, Song CH (2013) Hepatoprotective effect of water extract from Chrysanthemum indicum L. flower. Chin Med 8:7. doi:10.​1186/​1749-8546-8-7 CrossRef
  Jiang Q, Cao C, Lu S, Kivlin R, Wallin B, Chu W, Bi Z, Wang X, Wan Y (2009) MEK/ERK pathway mediates UVB-induced AQP1 downregulation and water permeability impairment in human retinal pigment epithelial cells. Int J Mol Med 23:771–777CrossRef
  Jinlian L, Yingbin Z, Chunbo W (2007) p38 MAPK in regulating cellular responses to ultraviolet radiation. J Biomed Sci 14:303–312. doi:10.​1007/​s11373-007-9148-4 CrossRef
  Jou PC, Feldman RJ, Tomecki KJ (2012) UV protection and sunscreens: what to tell patients. Cleve Clin J Med 79:427–436. doi:10.​3949/​ccjm.​79a.​11110 CrossRef
  Kim C, Ryu HC, Kim JH (2010) Low-dose UVB irradiation stimulates matrix metalloproteinase-1 expression via a BLT2-linked pathway in HaCaT cells. Exp Mol Med 42:833–841. doi:10.​3858/​emm.​2010.​42.​12.​086 CrossRef
  Korac RR, Khambholja KM (2011) Potential of herbs in skin protection from ultraviolet radiation. Pharmacogn Rev 5:164–173. doi:10.​4103/​0973-7847.​91114 CrossRef
  Lee ER, Kang YJ, Kim JH, Lee HT, Cho SG (2005) Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem 280:31498–31507. doi:10.​1074/​jbc.​M505537200 CrossRef
  Lee SJ, Cho SW, Kwon YY, Kwon HS, Shin WC (2012) Inhibitory effects of ethanol extracts from nuruk on oxidative stress, melanogenesis, and photo-aging. Mycobiology 40:117–123. doi:10.​5941/​MYCO.​2012.​40.​2.​117 CrossRef
  Lin E, Cavanaugh JE, Leak RK, Perez RG, Zigmond MJ (2008) Rapid activation of ERK by 6-hydroxydopamine promotes survival of dopaminergic cells. J Neurosci Res 86:108–117. doi:10.​1002/​jnr.​21478 CrossRef
  Liu J, Yang D, Minemoto Y, Leitges M, Rosner MR, Lin A (2006) NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta. Mol Cell 21:467–480. doi:10.​1016/​j.​molcel.​2005.​12.​020 CrossRef
  Lobner D, Liot G (2004) Role of MAPK/ERK in neurotrophin-4 potentiation of necrotic neuronal death. Neurochem Res 29:2303–2309CrossRef
  Nishigori C, Hattori Y, Toyokuni S (2004) Role of reactive oxygen species in skin carcinogenesis. Antioxid Redox Signal 6:561–570. doi:10.​1089/​1523086047739343​14 CrossRef
  Park CH, Lee MJ, Kim JP, Yoo ID, Chung JH (2006) Prevention of UV radiation-induced premature skin aging in hairless mice by the novel compound Melanocin A. Photochem Photobiol 82:574–578. doi:10.​1562/​2005-07-26-RA-623 CrossRef
  Park S, Lee JB, Kang S (2012) Topical application of Chrysanthemum indicum L. attenuates the development of atopic dermatitis-like skin lesions by suppressing serum IgE levels, IFN-gamma, and IL-4 in Nc/Nga mice. Evid Based Complement Alternat Med 2012:821967. doi:10.​1155/​2012/​821967
  Pognonec P (2009) ERK and cell death: overview. FEBS J 277:1. doi:10.​1111/​j.​1742-4658.​2009.​07365.​x CrossRef
  Quan T, Qin Z, Xia W, Shao Y, Voorhees JJ, Fisher GJ (2009) Matrix-degrading metalloproteinases in photoaging. J Investig Dermatol Symp Proc 14:20–24. doi:10.​1038/​jidsymp.​2009.​8 CrossRef
  Scharffetter-Kochanek K, Wlaschek M, Brenneisen P, Schauen M, Blaudschun R, Wenk J (1997) UV-induced reactive oxygen species in photocarcinogenesis and photoaging. Biol Chem 378(11):1247–1257
  Seite S, Fourtanier AM (2008) The benefit of daily photoprotection. J Am Acad Dermatol 58:S160–S166. doi:10.​1016/​j.​jaad.​2007.​04.​036 CrossRef
  Sena LA, Chandel NS (2012) Physiological roles of mitochondrial reactive oxygen species. Mol Cell 48:158–167. doi:10.​1016/​j.​molcel.​2012.​09.​025 CrossRef
  Trouba KJ, Hamadeh HK, Amin RP, Germolec DR (2002) Oxidative stress and its role in skin disease. Antioxid Redox Signal 4:665–673. doi:10.​1089/​1523086026022017​5 CrossRef
  Tsuji G, Takahara M, Uchi H, Takeuchi S, Mitoma C, Moroi Y, Furue M (2011) An environmental contaminant, benzo(a)pyrene, induces oxidative stress-mediated interleukin-8 production in human keratinocytes via the aryl hydrocarbon receptor signaling pathway. J Dermatol Sci 62(1):42–49. doi:10.​1016/​j.​jdermsci.​2010.​10.​017
  Vicentini FT, He T, Shao Y, Fonseca MJ, Verri WA Jr, Fisher GJ, Xu Y (2011) Quercetin inhibits UV irradiation-induced inflammatory cytokine production in primary human keratinocytes by suppressing NF-kappaB pathway. J Dermatol Sci 61:162–168. doi:10.​1016/​j.​jdermsci.​2011.​01.​002 CrossRef
  Wölfle U, Esser PR, Simon-Haarhaus B, Martin SF, Lademann J, Schempp CM (2011) UVB-induced DNA damage, generation of reactive oxygen species, and inflammation are effectively attenuated by the flavonoid luteolin in vitro and in vivo. Free Radic Biol Med 50:1081–1093. doi:10.​1016/​j.​freeradbiomed.​2011.​01.​027 CrossRef
  Xiang Y, Gao Q, Su W, Zeng L, Wang J, Hu Y, Nie W, Ma X, Zhang Y, Lee W (2012) Establishment, characterization and immortalization of a fibroblast cell line from the Chinese red belly toad Bombina maxima skin. Cytotechnology 64:95–105. doi:10.​1007/​s10616-011-9399-9 CrossRef
  Xiang Y, Wang X, Yan C, Gao Q, Li SA, Liu J, Zhou K, Guo X, Lee W, Zhang Y (2013) Adenosine-5′-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS ONE 8:e63759. doi:10.​1371/​journal.​pone.​0063759 CrossRef
  Zaid MA, Afaq F, Syed DN, Dreher M, Mukhtar H (2007) Inhibition of UVB-mediated oxidative stress and markers of photoaging in immortalized HaCaT keratinocytes by pomegranate polyphenol extract POMx. Photochem Photobiol 83:882–888. doi:10.​1111/​j.​1751-1097.​2007.​00157.​x CrossRef
  
• 作者单位：Sujiao Sun (1)
  Ping Jiang (3)
  Weiting Su (4)
  Yang Xiang (2)
  Jian Li (5)
  Lin Zeng (5)
  Shuangjuan Yang (5)
  
  1. Department of Cosmetology, The Affiliated Hospital of Dali College, Dali, 671000, Yunnan, China
  3. Department of Pathology, Kunming Medical University, Kunming, 650032, Yunnan, China
  4. State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, Yunnan, China
  2. Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, The Chinese Academy of Sciences, 32 East Jiao Chang Road, Kunming, 650223, Yunnan, China
  5. Kunming Biological Diversity Regional Center of Large Apparatuses and Equipment, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, Yunnan, China
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Biotechnology
  Biomedicine
  Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-0778

文摘

Wild chrysanthemum (Chrysanthemum indicum L.) is traditionally used in folk medicine as an anti-inflammatory agent. It is also used in the southwest plateau region of China to prevent ultraviolet-induced skin damage. However, the role and mechanism by which wild chrysanthemum prevents UV-induced skin damage and photoaging have never been investigated in vitro. In the present study, we found that aqueous extracts from wild chrysanthemum strongly reduced high-dose UVB-induced acute cell death of human immortalized keratinocytic HaCat cells. Wild chrysanthemum extract was also demonstrated to reduce low-dose UVB-induced expression of the photoaging-related matrix metalloproteinases MMP-2 and MMP-9. The ROS level elevated by UVB irradiation was strongly attenuated by wild chrysanthemum extract. Further study revealed that wild chrysanthemum extract reduced UVB-triggered ERK1/2 and p38 MAPK phosphorylation and their protective role, which is partially dependent on inhibiting p38 activation. These results suggest that wild chrysanthemum extract can protect the skin from UVB-induced acute skin damage and photoaging by reducing the intracellular reactive oxygen species (ROS) level and inhibiting p38 MAPK phosphorylation. The present study confirmed the protective role of wild chrysanthemum against UV-induced skin disorders in vitro and indicated the possible mechanism. Further study to identify the active components in wild chrysanthemum extract would be useful for developing new drugs for preventing and treating skin diseases, including skin cancer and photoaging, induced by UV irradiation.