Different Long-Term Outcomes of Abdominal Aortic Aneurysm and Intracranial Aneurysm Models: Hemodynamic Change may also Play an Essential Role in the Initiation and Progression of Abdominal Aortic Aneurysm in Rabbits

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• 作者：Yonghua Bi (1) (2)
  Xinwei Han (1)
  Hongshan Zhong (2) (3)
  Ke Xu (2) (3)
  Xun Qi (2) (3)
  Zhen Zhang (3) (4)
  Weixiao Li (2)
  
• 关键词：Hemodynamic ; Intracranial aneurysm ; Rabbit ; Abdominal aortic aneurysm
• 刊名：Cell Biochemistry and Biophysics
• 出版年：2014
• 出版时间：November 2014
• 年：2014
• 卷：70
• 期：2
• 页码：819-822
• 全文大小：156 KB
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• 作者单位：Yonghua Bi (1) (2)
  Xinwei Han (1)
  Hongshan Zhong (2) (3)
  Ke Xu (2) (3)
  Xun Qi (2) (3)
  Zhen Zhang (3) (4)
  Weixiao Li (2)
  
  1. Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People鈥檚 Republic of China
  2. Department of Radiology, The First Affiliated Hospital of China Medical University, 155 Nanjing Bei St, 110001, Shenyang, People鈥檚 Republic of China
  3. Key Laboratory of Diagnostic Imaging and Interventional Radiology of Liaoning Province, 110001, Shenyang, People鈥檚 Republic of China
  4. Department of Ultrasound, The First Affiliated Hospital of China Medical University, Shenyang, People鈥檚 Republic of China
  
• ISSN：1559-0283

文摘

Self-healing phenomenon was found in the periarterial elastase-induced abdominal aortic aneurysm (AAA) in rabbit. This kind of aneurysm model does not progress and heals spontaneously in the long term, which is quite different from the performance of AAA disease in human. In order to better mimic human AAA and overcome this shortcoming of traditional AAA model in rabbit, we studied the pathogenesis of cerebral aneurysm (CA) model in small animal, which shows an excellent long-term patency and progressive enlargement. We found that hemodynamic conditions, such as turbulence flow, high blood flow, and shear stress, play an important role in the formation and progression of CA. So, we hypothesize that hemodynamic change may also play an essential role in the initiation and progression of rabbit AAA, and self-healing will be overcome if hemodynamic condition changes by coarctation of infra-renal aorta after elastase incubation.