Nodal Skip Metastasis is not a Predictor of Survival in Thoracic Esophageal Squamous Cell Carcinoma

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• 作者：Zhengfei Zhu MD (1) (5)
  Weiwei Yu MD (2)
  Hecheng Li MD (3) (5)
  Kuaile Zhao MD (1) (5)
  Weixin Zhao MD (1) (5)
  Yawei Zhang MD (3) (5)
  Menghong Sun MD (4) (5)
  Qiao Wei MD (4) (5)
  Haiquan Chen MD (3) (5)
  Jiaqing Xiang MD (3) (5)
  Xiaolong Fu MD (1) (5)
  
• 刊名：Annals of Surgical Oncology
• 出版年：2013
• 出版时间：September 2013
• 年：2013
• 卷：20
• 期：9
• 页码：3052-3058
• 全文大小：320KB
• 参考文献：1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. / Int J Cancer. 2010;127:2893-17. CrossRef
  2. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. / CA Cancer J Clin. 2011;61:69-0. CrossRef
  3. Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A. / American joint committee on cancer (AJCC) cancer staging manual, 7th edn. Chicago: Springer; 2010:67-2.
  4. Tachibana M, Kinugasa S, Hirahara N, Yoshimura H. Lymph node classification of esophageal squamous cell carcinoma and adenocarcinoma. / Eur J Cardiothorac Surg. 2008;34:427-1. CrossRef
  5. Riquet M, Assouad J, Bagan P, Foucault C, Le Pimpec Barthes F, Dujon A, Danel C. Skip mediastinal lymph node metastasis and lung cancer: a particular N2 subgroup with a better prognosis. / Ann Thorac Surg. 2005;79:225-3. CrossRef
  6. Nakagiri T, Sawabata N, Funaki S, Inoue M, Kadota Y, Shintani Y, Okumura M. Validation of pN2 sub-classifications in patients with pathological stage IIIA N2 non-small cell lung cancer. / Interact Cardiovasc Thorac Surg. 2011;12:733-. CrossRef
  7. Lim YC, Koo BS. Predictive factors of skip metastases to lateral neck compartment leaping central neck compartment in papillary thyroid carcinoma. / Oral Oncol. 2012;4:262-65. CrossRef
  8. Lee SE, Lee JH, Ryu KW, et al. Sentinel node mapping and skip metastases in patients with early gastric cancer. / Ann Surg Oncol. 2009;16:603-08. CrossRef
  9. Keskek M, Balas S, Gokoz A, Sayek I. Re-evaluation of axillary skip metastases in the era of sentinel lymph node biopsy in breast cancer. / Surg Today. 2006;36:1047-052. CrossRef
  10. Li H, Zhang Y, Cai H, Xiang J. Pattern of lymph node metastases in patients with squamous cell carcinoma of the thoracic esophagus who underwent three-field lymphadenectomy. / Eur Surg Res. 2007;39:1-. CrossRef
  11. Li H, Yang S, Zhang Y, Xiang J, Chen H. Thoracic recurrent laryngeal lymph node metastases predict cervical node metastases and benefit from three-field dissection in selected patients with thoracic esophageal squamous cell carcinoma. / J Surg Oncol. 2012;105:548-52. CrossRef
  12. Japanese Society for Esophageal Diseases: Guidelines for the clinical and pathologic studies on carcinoma of the esophagus. / Jpn J Surg. 1976;6:69-8. CrossRef
  13. Prenzel KL, Bollschweiler E, Schr?der W, M?nig SP, Drebber U, Vallboehmer D, H?lscher AH. Prognostic relevance of skip metastases in esophageal cancer. / Ann Thorac / Surg. 2010;90:1662-667. CrossRef
  14. Hosch SB, Stoecklein NH, Pichlmeier U, et al. Esophageal cancer: the mode of lymphatic tumor cell spread and its prognostic significance. / J Clin Oncol. 2001;19:1970-975.
  15. Xu QR, Zhuge XP, Zhang HL, Ping YM, Chen LQ. The N-classification for esophageal cancer staging: should it be based on number, distance, or extent of the lymph node metastasis? / World J Surg. 2011;35:1303-310. CrossRef
  16. Skandalakis JE, Ellis H. Embryologic and anatomic basis of esophageal surgery. / Surg Clin North Am. 2000;80:85-55. CrossRef
  17. Takeuchi H, Fujii H, Ando N, et al. Validation study of radio-guided sentinel lymph node navigation in esophageal cancer. / Ann Surg. 2009;249:757-63. CrossRef
  18. Kim HK, Kim S, Park JJ, Jeong JM, Mok YJ, Choi YH. Sentinel node identification using technetium-99m neomannosyl human serum albumin in esophageal cancer. / Ann / Thorac Surg. 2011;91:1517-522. CrossRef
  19. Chen J, Liu S, Pan J, et al. The pattern and prevalence of lymphatic spread in thoracic oesophageal squamous cell carcinoma. / Eur J Cardiothorac Surg. 2009;36:480-86. CrossRef
  20. Groth SS, Virnig BA, Whitson BA, DeFor TE, Li ZZ, Tuttle TM, Maddaus MA. Determination of the minimum number of LNs to examine to maximize survival in patients with esophageal carcinoma: data from the Surveillance Epidemiology and End Results database. / J Thorac Cardiovasc Surg. 2010;139:612-20. CrossRef
  21. National Comprehensive Cancer Network. Esophageal Cancer Version v.2.2012. Available: http://www.nccn.org/professionals/physician_gls/PDF/esophageal.pdf. Accessed 31 May 2012.
  22. Gusterson B, Ott R. Occult axillary lymph-node micrometastases in breast cancer. / Lancet. 1990;336:434-35. CrossRef
  23. Yekebas EF, Schurr PG, Kaifi JT, et al. Effectiveness of radical en bloc esophagectomy compared to transhiatal esophagectomy in squamous cell cancer of the esophagus is influenced by nodal micrometastases. / J Surg Oncol. 2006;93:541-49. CrossRef
  24. Izbicki JR, Hosch SB, Pichlmeier U, et al. Prognostic value of immunohistochemically identifiable tumor cells in LNs of patients with completely resected esophageal cancer. / N Engl J Med. 1997;337:1188-194. CrossRef
  
• 作者单位：Zhengfei Zhu MD (1) (5)
  Weiwei Yu MD (2)
  Hecheng Li MD (3) (5)
  Kuaile Zhao MD (1) (5)
  Weixin Zhao MD (1) (5)
  Yawei Zhang MD (3) (5)
  Menghong Sun MD (4) (5)
  Qiao Wei MD (4) (5)
  Haiquan Chen MD (3) (5)
  Jiaqing Xiang MD (3) (5)
  Xiaolong Fu MD (1) (5)
  
  1. Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
  5. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
  2. Department of Radiation Oncology, Six Hospital of Jiao Tong University, Shanghai, China
  3. Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
  4. Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China
  

文摘

Background The presence of nodal skip metastasis (NSM) has been found to be of clinical importance in non-small cell lung cancer, but the study of this phenomenon in esophageal carcinoma is relatively rare. The purpose of this study was to identify risk factors influencing NSM and to assess its prognostic value in thoracic esophageal squamous cell carcinoma (ESCC). Methods A total of 207 patients with thoracic ESCC who underwent three-field lymphadenectomy and who had lymph node metastasis were reviewed. Associations of NSM occurrence with the clinicopathological characteristics of patients and primary tumors were evaluated using logistic regression analysis. The influence of NSM on the overall survival (OS) was assessed by log-rank tests and Cox regression analysis. Results NSM were present in 58 (26?%) patients. No factor was significantly associated with the incidence of NSM except for the location of primary tumor. There were no NSMs in the 29 patients from our study with upper thoracic ESCC, and the rates of tumors occurrence in the middle and lower third of the esophagus were 38.9 and 14.9?%, respectively. The median OS was 30?months, and no significant difference in OS was found between the patients with or without NSM (p?=?0.767). Only N status was found to be the independent risk factor for OS by Cox multivariate analysis. Conclusions NSM is common in thoracic ESCC, especially in patients with tumors located in the middle and lower third of the esophagus. However, the presence of NSM did not predict prognosis.