Number of Negative Lymph Nodes is Associated with Survival in Thoracic Esophageal Squamous Cell Carcinoma Patients Undergoing Three-Field Lymphadenectomy

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• 作者：Zhengfei Zhu MD (1) (5)
  Haiquan Chen MD (2) (5)
  Weiwei Yu MD (3)
  Xiaolong Fu MD (1) (5)
  Jiaqing Xiang MD (2) (5)
  Hecheng Li MD (2) (5)
  Yawei Zhang MD (2) (5)
  Menghong Sun MD (4) (5)
  Qiao Wei MD (4) (5)
  Weixin Zhao MD (1) (5)
  Kuaile Zhao MD (1) (5)
  
• 刊名：Annals of Surgical Oncology
• 出版年：2014
• 出版时间：September 2014
• 年：2014
• 卷：21
• 期：9
• 页码：2857-2863
• 全文大小：229 KB
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• 作者单位：Zhengfei Zhu MD (1) (5)
  Haiquan Chen MD (2) (5)
  Weiwei Yu MD (3)
  Xiaolong Fu MD (1) (5)
  Jiaqing Xiang MD (2) (5)
  Hecheng Li MD (2) (5)
  Yawei Zhang MD (2) (5)
  Menghong Sun MD (4) (5)
  Qiao Wei MD (4) (5)
  Weixin Zhao MD (1) (5)
  Kuaile Zhao MD (1) (5)
  
  1. Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
  5. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
  2. Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
  3. Department of Radiation Oncology, Six Hospital of Jiao Tong University, Shanghai, China
  4. Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China
  
• ISSN：1534-4681

文摘

Background The number of negative lymph nodes (NLNs) can be used for predicting clinical outcomes for patients with esophageal carcinoma as it is believed to reflect the extent of lymphadenectomy. However, when patients are treated with the same surgical procedure, its prognostic value is not clear. Methods We reviewed the records of 332 patients with thoracic esophageal squamous cell carcinoma (ESCC) who underwent three-field lymphadenectomy (3FLND) and had at least 15 lymph nodes removed. We used Kaplan–Meier estimates to compute overall survival (OS), the log-rank tests to assess the equality of survival rates, and Cox regression analyses to evaluate the association between survival and NLN count after adjusting for potential confounders. Results At a median follow-up interval of 36?months, the median OS was 47?months and the 5-year survival rate was 47.0?%. NLN count was independently associated with OS, and higher numbers of NLNs were linked to better OS (hazard ratio [HR] 0.970; 95?% confidence interval [CI] 0.955-.986); the effect did not change after we stratified patients into node-negative (HR 0.966; 95?% CI 0.933-.000) and node-positive (HR 0.973; 95?% CI 0.955-.991) groups. Conclusion The NLN count is an important independent prognostic factor for patients with thoracic ESCC treated with 3FLND.