Acute toxicological impact of nano- and submicro-scaled zinc oxide powder on healthy adult mice

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• 作者：Bing Wang ; Weiyue Feng ; Meng Wang ; Tiancheng Wang ; Yiqun Gu ; Motao Zhu ; Hong Ouyang ; Junwen Shi ; Fang Zhang and Yuliang Zhao ; et al.
• 关键词：Acute oral toxicity ; Nano ; meter zinc oxide powder ; Submicro ; meter zinc oxide powder ; Mice ; Toxicology ; Health effects ; Medicine
• 刊名：Journal of Nanoparticle Research
• 出版年：2008
• 出版时间：February, 2008
• 年：2008
• 卷：10
• 期：2
• 页码：263-276
• 全文大小：891.3 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nanotechnology
  Inorganic Chemistry
  Characterization and Evaluation Materials
  Physical Chemistry
  Applied Optics, Optoelectronics and Optical Devices
  
• 出版者：Springer Netherlands
• ISSN：1572-896X

文摘

In this work, the acute oral toxicity of 20- and 120-nm ZnO powder at doses of 1-, 2-, 3-, 4-, 5-g/kg body weight was evaluated referred to the OECD guidelines for testing of chemicals. As the results, both 20- and 120-nm ZnO belong to non-toxic chemicals according to the Globally Harmonized Classification System (GHS) for the classification of chemicals. The distribution determination showed that Zn was mainly retained in the bone, kidney and pancreas after 20- and 120-nm ZnO administration. However, the results of blood measurement suggest that the increase in blood viscosity could be induced by low and median dose of 20-nm ZnO but high dose of 120-nm ZnO. The pathological examination showed that the 120-nm ZnO treated mice had dose–effect pathological damages in stomach, liver, heart and spleen, whereas, 20-nm ZnO displayed negative dose–effect damages in liver, spleen and pancreas. Therefore, we conclude that the liver, spleen, heart, pancreas and bone are the target organs for 20- and 120-nm ZnO oral exposure. More attention should be paid on the potential toxicity induced by low dose of 20-nm ZnO oral exposure.