Two new bicyclic sulfoxides from Welsh onion
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- 作者：Toshihiro Nohara ; Yukio Fujiwara ; Tsuyoshi Ikeda…
- 关键词：Allium fistulosum ; Bicyclic sulfoxide ; Welsonin A1 ; Tetrahydrothiophene derivative ; M2 macrophage ; Anticancer function
- 刊名：Journal of Natural Medicines
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：70
- 期：2
- 页码：260-265
- 全文大小：723 KB
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Yukio Fujiwara (2)
Tsuyoshi Ikeda (1)
Kotaro Murakami (1)
Masateru Ono (3)
Mona El-Aasr (4)
Daisuke Nakano (5)
Junei Kinjo (5)
1. Faculty of Pharmaceutical Sciences, Sojo University, 22-1, 4-Chome, Nishi-ku, Ikeda, Kumamoto, 860-0082, Japan
2. Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan
3. School of Agriculture, Tokai University, 5435 Minamiaso, Aso, Kumamoto, 869-1404, Japan
4. Faculty of Pharmacy, Tanta University, Tanta, 31111, Egypt
5. Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan - 刊物主题：Pharmacology/Toxicology; Plant Sciences; Complementary & Alternative Medicine; Medicinal Chemistry; Pharmacy;
- 出版者：Springer Japan
- ISSN：1861-0293
文摘
Newly identified bicyclic sulfoxides, welsonins A1 (1) and A2 (2), were isolated from acetone extracts of the bulbs of the Welsh onion (Allium fistulosum). In this study, the structures of 1 and 2, which are tetrahydrothiophene-S-oxide derivatives, were characterized by spectroscopic analysis. These compounds appeared to be derived from the coupling of 1-propenyl sulfenic acid and uronic acid. Welsonin A1 (1) showed the potential to suppress tumor-cell proliferation by inhibiting the polarization of alternatively activated M2 macrophages.