Evaluation of M307 of FUT1 gene as a genetic marker for disease resistance breeding of sutai pigs

详细信息    查看全文

• 作者：Wen-bin Bao (1)
  Lan Ye (1)
  Jing Zhu (1)
  Zhang-yuan Pan (1)
  Guo-qiang Zhu (2)
  Xue-gen Huang (3)
  Sheng-long Wu (1) wenbinbao74@yahoo.com
• 关键词：FUT1 – Swine – Immune indexe – Production performance – Disease resistance breeding
• 刊名：Molecular Biology Reports
• 出版年：2012
• 出版时间：April 2012
• 年：2012
• 卷：39
• 期：4
• 页码：4223-4228
• 全文大小：221.4 KB
• 参考文献：1. Imberechts H, De Greve H, Schlicker C, Bouchet H, Pohl P, Charlier G, Bertschinger H, Wild P, Vandekerckhove J, van Damme J (1992) Characterization of F107 fimbriae of Escherichia coli 107/86, which causes oedema disease in pigs and nucleotide sequence of F107 major fimbrial subunit gene, fedA. Infect Immun 60:1963–1971
  2. Benin AM, Ducher-Suchaux MF (1991) Relationship between virulence and adherence of various enterotoxigenic Escherichia coli: strains to isolated intestinal epithelial cells from Chinese Meishan and European large white pigs. Am J Vet Res 52:45–49
  3. Nagy B, Fekete PZ (1999) Enterotoxigenic Escherichia coli (ETEC) in farm animal. Vet Res 30:259–284
  4. Vogeli P, Meijerink E, Fries R, Stricker C, Bertschinger HU (1997) A molecular test for the detection of E. coli F18 receptors: a breakthrough in the struggle against oedema and post-weaning diarrhoea in swine. Schweiz Arch Tierheilk 139:479–484
  5. Meijerink E, Fries R, Vogeli P, Masabanda J, Wigger G, Stricker C, Neuenschwander S, Bertschinger HU, Stranzinger G (1997) Two α (1,2) fucosyltransferase genes on porcine chromosome 6q11 are closely linked to the blood group inhibitor (S) and Escherichia coli F18 receptor (ECF18R) Loci. Mamm Genome 8:736–741
  6. Yan XM, Guo YM, Ding NS, Ren J, Huang LS (2004) Study on the genetic variation of a 1-fucosytransferase gene in different pig breed. Chin J Anim Sci 40:8–10
  7. Shi QS, Huang SQ, Liu XC, He CQ, Jiang J (2003) Polymorphism of E. coli F18 receptor gene in different pig breeds. Acta Genet Sin 30:221–224
  8. Wu SL, Yuan ZW, Ju HP, Zhu GQ, Wang JY, Song CY, Chen GH (2006) Study on genetically susceptible piglets of small intestinal epithelium receptors to pathogenic F18 fimbrial Escherichia coli adhesion in vitro. Chin J Vet Sci 26:622–625
  9. Bao WB, Wu SL, Musa HH, Zhu GQ, Chen GH (2008) Genetic variation at the alpha (1) fucosyltransferase (FUT1) gene in Asian wild boar and Chinese and Western commercial pig breeds. J Anim Breed Genet 125:427–430
  10. Sambrook J, Russell DW (2001) Molecular cloning: a laboratory manual. CSHL Press, New York
  11. Wang SQ, Zhang XC (2003) Introduction of a new modified Wright’s stain on blood smears. J Pract Med Technol 10:202
  12. An LY (2000) Veterinary laboratory diagnosis. China Agricultural University Publishing House, Beijing
  13. Wu CM, Zhao GP, Wen J, Chen JL, Zheng MQ, Chen GH (2007) Diversity of immune traits between Chinese Beijing-You Chicken and White Leghorn. Acta Vet Et Zootech 38:1383–1388
  14. Chen Z, Zhao XF, Jiang XL, Guo XL, Lv ZZ, Zhou HM, Xu NY (2011) Association of PPAR_2 polymorphisms with carcass and meat quality traits in a Pietrain × Jinhua F2 population. Genet Mole Bio 34:56–61
  15. Ma XY, Lin YC, Jiang ZY, Zheng CT, Zhou GL, Yu DQ, Cao T, Wang J, Chen F (2010) Dietary arginine supplementation enhances antioxidative capacity and improves meat quality of finishing pigs. Amino Acids 38:95–102
  16. Al-Murrani WK, Kassab A, Al-Sam HZ, Al-Athari A (1997) Heterophil/lymphocyte ratio as a selection criterion for heat stress in domestic fowl. Poultry Sci 38:159–163
  17. Stevenson JR, Taylor R (1988) Effects of glucocorticoid and anti glucocorticoid hormones on leukocyte numbers and functions. Immunology 10:1–6
  18. Kassab AK, Elaiwi HH, Al-Murrani WK (2000) Heterophil/lymphocyte ratio under high and low temperature stress as a selection criterion for immune response against Newcastle antigen in chicken. J Agric Res 10:184–187
  19. Latimer KS, Tang KN, Goodwin MA, Steffens WL, Brown J (1988) Leukocyte changes associated with acute inflammation in chickens. Avian Dis 32:760–772
  20. Siegel PB, Gross WB, Cherry JA (1982) Correlated response of chickens to selection for production of antibody to sheep erythrocytes. Anim Blood Gr Biochem Genet 13:291–295
  21. Dunnington EA, Martin A, Briles WE, Briles RW, Siegel PB (1986) Resistance to Marek’s disease in chickens selected for high and low antibody responses to sheep red blood cells. Arch Fur Geflugelkunde 50:94–96
  22. He XP, Peng YB, Fan B, Li K, Zhu MJ, Peng ZZ (2006) Study on the detection of swine α-1 fucosytransferase polymorphism and its correlation with traits. Swine Prod 3:26–28
  23. Jiang XP, Liu YG, Xiong YZ, Deng CY (2005) Effects of FUT1 gene on meat quality and carcass traits in swine. HEREDITAS (Beijing) 27:566–570
• 作者单位：1. Key Laboratory for Animal Genetics, Breeding, Reproduction and Molecular Design of Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009 China2. College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009 China3. Suzhou Taihu Pig Breeding Center, Suzhou, 215000 Jiangsu, China
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Animal Anatomy, Morphology and Histology
  Animal Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-4978

文摘

Alpha (1,2) fucosyltransferase (FUT1) gene has been identified as a candidate gene for controlling the expression of the receptor for ETEC F18. The genetic variations in the position of M307 nucleotide in open reading frame of FUT1 have been proposed as a marker for selecting ETEC F18 resistant pigs. The polymorphisms of M307 in FUT1 of breeding base group for ETEC F18 resistance of Sutai pigs (Duroc × Meishan) was detected and their correlations to some immune indexes, growth and development ability, carcass traits and meat quality were also analyzed, which aimed to investigate feasibility of further breeding for diseases resistance based on M307 of FUT1 for Sutai pigs. After digested by Hin6 I, M307 of FUT1 gene could be divided into three kinds of genotypes, AA, AG, and GG. The frequencies were 0.235, 0.609, and 0.156, respectively. The results indicated that Sutai pigs with the AA genotype in M307 of FUT1 gene not only have relatively strong general disease resistance ability in piglets, but also have higher growth and development ability and stable carcass traits and meat quality. It is entirely feasible to raise the new strains of Sutai pigs resistant to Escherichia coli F18 based on genetic marker of the M307 position in FUT1gene.