Robustness of Radiomic Features in [11C]Choline and [18F]FDG PET/CT Imaging of Nasopharyngeal Carcinoma: Impact of Segmentation and Discretization
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- 作者：Lijun Lu ; Wenbing Lv ; Jun Jiang ; Jianhua Ma ; Qianjin Feng…
- 关键词：Key words[11C]choline ; [18F]FDG ; PET ; Radiomic ; Nasopharyngeal carcinoma
- 刊名：Molecular Imaging and Biology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：18
- 期：6
- 页码：935-945
- 全文大小：1,959 KB
- 刊物主题：Imaging / Radiology;
- 出版者：Springer US
- ISSN：1860-2002
- 卷排序：18
文摘
PurposeRadiomic features are increasingly utilized to evaluate tumor heterogeneity in PET imaging and to enable enhanced prediction of therapy response and outcome. An important ingredient to success in translation of radiomic features to clinical reality is to quantify and ascertain their robustness. In the present work, we studied the impact of segmentation and discretization on 88 radiomic features in 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) and [11C]methyl-choline ([11C]choline) positron emission tomography/X-ray computed tomography (PET/CT) imaging of nasopharyngeal carcinoma.