Antioxidative properties of 4-methylumbelliferone are related to antibacterial activity in the silkworm (Bombyx mori) digestive tract
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- 作者：Yan Fang (1) (2)
Hua Wang (1) (2)
Wenjuan Zhu (1) (2)
Lu Wang (1) (2)
Hengjiang Liu (1) (2)
Xu Xu (1) (2)
Weimin Yin (1) (2)
Yanghu Sima (1) (2)
Shiqing Xu (1) (2) - 关键词：4 ; Methylumbelliferone ; Antioxidant activity ; Antibacterial capacity ; Bombyx mori
- 刊名：Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology
- 出版年：2014
- 出版时间：August 2014
- 年：2014
- 卷：184
- 期：6
- 页码：699-708
- 全文大小：3,651 KB
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26. Zhang W, Jiang M (2010) Synthesis and antifungal activities of umbelliferone analogs. Chin J Org Chem 30:254-59 (In Chinese) - 作者单位：Yan Fang (1) (2)
Hua Wang (1) (2)
Wenjuan Zhu (1) (2)
Lu Wang (1) (2)
Hengjiang Liu (1) (2)
Xu Xu (1) (2)
Weimin Yin (1) (2)
Yanghu Sima (1) (2)
Shiqing Xu (1) (2)
1. Department of Applied Biology, School of Biology and Basic Medical Sciences, Medical College, Soochow University, Suzhou, 215123, China
2. National Engineering Laboratory for Modern Silk, Institute of Agricultural Biotechnology and Ecology, Soochow University, Suzhou, 215123, China - ISSN：1432-136X
文摘
Umbelliferones have gained significant attention due to their tumor-inhibitory effects in vitro. This study was undertaken to examine the impact of umbelliferones in an invertebrate model organism, Bombyx mori, to assess the underlying antimicrobial activities via antioxidation in vivo. Oral administration of 4?mM 4-methylumbelliferone (4-MU), a model umbelliferone drug, in B. Mori larvae caused a rapid increase in reactive oxygen species, such as hydrogen peroxide (H2O2) and antimicrobial activity in the digestive tract. In addition, a significant increase in total antioxidant capacity as well as superoxide anion radical-inhibiting activity and reduced glutathione were detected. The antioxidant defense system was activated following induction of H2O2, resulting in a significant rise in catalase (50-6?%) and glutathione peroxidase (175?%) activities, which were helpful in defending digestive tract cells against oxidative injury. These results help in understanding the anticancer mechanism of 4-MU based on its antioxidation in organisms.