Physiological and Pathological Properties of Interleukin-22 in Liver Diseases

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• 作者：Xiaoni Kong ; Wenjun Liu ; Qiang Xia ; Fouad Lafdil
• 关键词：Interleukin 22 ; IL ; 22R1 ; Hepatocytes ; HSCs ; LPCs ; Liver diseases
• 刊名：Current Pathobiology Reports
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：3
• 期：4
• 页码：307-313
• 全文大小：591 KB
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• 作者单位：Xiaoni Kong (1)
  Wenjun Liu (2)
  Qiang Xia (1)
  Fouad Lafdil (3) (4)
  
  1. Department of Liver Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai, 200127, China
  2. State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China
  3. University of Paris-Est-Cr茅teil, Cr茅teil, France
  4. INSERM U955, IMRB H么pital Henri Mondor, 51 Avenue du Mar茅chal de Lattre de Tassigny, 94000, Cr茅teil, France
  
• 刊物主题：Pathology;
• 出版者：Springer US
• ISSN：2167-485X

文摘

Interleukin-22 (IL-22) belongs to IL-10 cytokine family which was initially described as a T helper 1 (Th1) and 17 (Th17) cytokine. Subsequently, numerous other sources were identified. The liver is often described as an immunological organ due to its particular contain in a large spectrum of immune cells of which certain subsets produce IL-22. In liver, expression of IL-22 receptor subunit-1 (IL-22R1), is restricted to hepatocytes, hepatic stellate cells, and liver progenitor cells which are involved in several hepatic diseases. IL-22 is known to play protective roles mainly through signal transducer of activator of transcription-3 (STAT3)-dependant signaling pathways. However, possible deleterious effects of IL-22 at specific stages along with the progression of the diseases and according to the etiology were reported. This review summarizes the current understandings of both beneficial and deleterious facets of IL-22 in liver diseases and discusses its putative targeting as a strategy for further clinical trials. Keywords Interleukin 22 IL-22R1 Hepatocytes HSCs LPCs Liver diseases