Cyclooxygenase 2 promoted the tumorigenecity of pancreatic cancer cells
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  • 作者:Wenjun Li (1)
    Zhengfa Mao (2)
    Xin Fan (2)
    Lei Cui (2)
    Xuqing Wang (2)
  • 关键词:Cox2 ; Pancreatic cancer ; Cell growth ; Cell migration
  • 刊名:Tumor Biology
  • 出版年:2014
  • 出版时间:March 2014
  • 年:2014
  • 卷:35
  • 期:3
  • 页码:2271-2278
  • 全文大小:3,707 KB
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  • 作者单位:Wenjun Li (1)
    Zhengfa Mao (2)
    Xin Fan (2)
    Lei Cui (2)
    Xuqing Wang (2)

    1. Department of Oncology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China
    2. Department of General Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China
  • ISSN:1423-0380
文摘
Pancreatic cancer is one of the leading causes of cancer-related death in the world. It is very urgent to find new therapeutic targets and improve the treatment. Cyclooxygenase 2 (Cox2), a regulator of inflammation signaling, has been found to be involved in tumorigenesis of various tumor types. However, its biological functions in pancreatic cancer cells are not fully understood. Here, we found that the expression of Cox2 was elevated in pancreatic cancer tissues compared with that in the paired normal tissues. The over-expression of Cox2 in pancreatic cancer cells promoted cell proliferation and migration, while the knockdown of the expression of Cox2 inhibited the tumorigenesis of pancreatic cancer cells in vitro and in vivo. Mechanistically, Cox2 regulated the expression of multiple genes involved in cell growth, migration, and cell apoptosis. Taken together, our study revealed the pivotal function of Cox2 in pancreatic cancer, and Cox2 might be an important therapeutic target for the treatment.

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