iRhom2 Uncv mutation blocks bulge stem cells assuming the fate of hair follicle

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• 作者：Leilei Yang ; Wenlong Li ; Bing Liu ; Shaoxia Wang…
• 刊名：Archives of Dermatological Research
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：308
• 期：7
• 页码：503-510
• 全文大小：1,865 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Dermatology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-069X
• 卷排序：308

文摘

iRhom2 is necessary for maturation of TNFα-converting enzyme, which is required for the release of tumor necrosis factor. In the previous study, we found that the iRhom2Uncv mutation in N-terminal cytoplasmic domain-encoding region (iRhom2Uncv) leads to aberrant hair shaft and inner root sheath differentiation, thus results in a hairless phenotype in homozygous iRhom2Uncv/Uncv BALB/c mice. In this study, we found iRhom2 mutation decreased hair matrix proliferation, however, iRhom2Uncv/Uncv mice displayed hyperproliferation and hyperkeratosis in the interfollicular epidermis along with hypertrophy in the sebaceous glands. The number of bulge SCs was not altered and the hair follicle cycle is normal in iRhom2Uncv/Uncv mice. The decreased proliferation in hair matrix but increased proliferation in epidermis and sebaceous glands in iRhom2Uncv/Uncv mice may implying that iRhom2Uncv mutation blocks bugle stem cells assuming the fate of hair follicle. This study identifies iRhom2 as a novel regulator for determination of keratinocyte lineages.KeywordsiRhom2Hair follicle stem cellDifferentiationInterfollicular epidermisSebaceous glands