Thalamic resting-state functional connectivity: disruption in patients with type 2 diabetes

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• 作者：Yu-Chen Chen ; Wenqing Xia ; Cheng Qian ; Jie Ding ; Shenghong Ju…
• 关键词：T2DM ; Thalamus ; Functional connectivity ; FMRI
• 刊名：Metabolic Brain Disease
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：30
• 期：5
• 页码：1227-1236
• 全文大小：1,113 KB
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• 作者单位：Yu-Chen Chen (1)
  Wenqing Xia (2)
  Cheng Qian (1)
  Jie Ding (1)
  Shenghong Ju (1)
  Gao-Jun Teng (1)
  
  1. Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, 87# Dingjiaqiao Road, Nanjing, 210009, China
  2. Medical School, Southeast University, Nanjing, China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Neurosciences
  Neurology
  Biochemistry
  Oncology
  
• 出版者：Springer Netherlands
• ISSN：1573-7365

文摘

To explore the disrupted thalamic functional connectivity and its relationships with cognitive dysfunction in type 2 diabetes mellitus (T2DM) by using resting-state functional magnetic resonance imaging (fMRI). A total of 38 T2DM patients and 39 well-matched healthy controls participated in the resting-state fMRI and T1-weighted imaging scans. The thalamic functional connectivity was characterized by using a seed-based whole-brain correlation method and compared T2DM patients with healthy controls. Pearson correlation analysis was performed between thalamic functional connectivity and clinical data. When compared with healthy controls, T2DM showed significantly decreased functional connectivity of the thalamus mainly in the right middle temporal gyrus (MTG), right precentral gyrus and bilateral occipital cortex; Increased functional connectivity of the thalamus was detected in the left cerebellum, bilateral middle frontal gyrus and middle cingulate gyrus (p < 0.05, corrected for AlphaSim). In T2DM patients, the decreased thalamic functional connectivity of the right MTG was positively associated with the Verbal Fluency Test score (r = 0.438, p = 0.006). Meanwhile, the decreased thalamic functional connectivity of the right cuneus was positively correlated with the Complex Figure Test-delayed score and negatively correlated with the Trail Making Test-B score, respectively (r = 0.492, p = 0.002; r = ?.504, p = 0.001). Moreover, there was no structural damage in the thalamus of T2DM patients. T2DM patients develop disrupted thalamocortical functional connectivity, which is associated with cognitive impairment in selected brain regions. Resting-state thalamocortical connectivity disturbance may play a central role in the underlying neuropathological process of T2DM-related cognitive dysfunction. Keywords T2DM Thalamus Functional connectivity FMRI