Measuring biomarkers of acute kidney injury during renal replacement therapy: wisdom or folly?

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• 作者：Marlies Ostermann (16)
  Lui G Forni (17) (18)
  
  16. Department of Critical Care & Nephrology ; Guy鈥檚 & St Thomas鈥?Hospital ; Westminster Bridge Road ; London ; SE1 9RT ; United Kingdom
  17. Department of Critical Care ; Western Sussex Foundation Hospitals Trust ; Lyndhurst Road ; Worthing ; West Sussex ; BN11 2DH ; United Kingdom
  18. Brighton & Sussex Medical School ; Falmer ; Brighton ; BN1 9PX ; United Kingdom
  
• 刊名：Critical Care
• 出版年：2014
• 出版时间：June 2014
• 年：2014
• 卷：18
• 期：3
• 全文大小：125 KB
• 参考文献：1. Schilder, L, Nurmohamed, SA, ter Wee, PM, Paauw, NJ, Girbes, AR, Beishuizen, A, Beelen, RH, Groeneveld, AB (2014) The plasma level and biomarker value of neutrophil gelatinase-associated lipocalin in critically ill patients with acute kidney injury are not affected by continuous venovenous hemofiltration and anticoagulation applied. Crit Care 18: pp. R78 CrossRef
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  3. Haase, M, Bellomo, R, Devarajan, P, Schlattmann, P, Haase-Fielitz, A (2009) Accuracy of neutrophil gelatinase associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta analysis. Am J Kidney Dis 54: pp. 1012-1024 CrossRef
  4. Ostermann, M, Philips, BJ, Forni, LG (2012) Biomarkers of acute kidney injury: where are we now?. Crit Care 16: pp. 233 CrossRef
  5. Kashani, K, Al-Khafaji, A, Ardiles, T, Artigas, A, Bagshaw, SM, Bell, M, Bihorac, A, Birkhahn, R, Cely, CM, Chawla, LS, Davison, DL, Feldkamp, T, Forni, LG, Gong, MN, Gunnerson, KJ, Haase, M, Hackett, J, Honore, PM, Hoste, EA, Joannes-Boyau, O, Joannidis, M, Kim, P, Koyner, JL, Laskowitz, DT, Lissauer, ME, Marx, G, McCullough, PA, Mullaney, S, Ostermann, M, Rimmel茅, T (2013) Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care 17: pp. R25 CrossRef
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• 刊物主题：Intensive / Critical Care Medicine; Emergency Medicine;
• 出版者：BioMed Central
• ISSN：1364-8535

文摘

Early data are now appearing relating to the measurement of biomarkers of acute kidney injury during renal replacement therapy. These data go some way in describing the clearance of these molecules during renal support. Understanding the potential clearance, or otherwise, of these proteins may lead to directing our therapies in the future particularly with regard to cessation of renal support. We describe a recent study which has provided data that may aid in addressing this issue.